Purinergic receptors in the splanchnic circulation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Manuela Morato (Autor) FFUP; Teresa Sousa (Autor) FFUP; António Albino-Teixeira (Autor) Outra

Revista

Título: Purinergic Signalling

Vol. 4 Nº 3

Páginas: 267-285

ISSN: 1573-9538

Editora: Springer Nature

Indexação

ISI Web of Science

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

CORDIS: Ciências da Saúde

Outras Informações

Resumo (PT): There is considerable evidence that purines are vasoactive molecules involved in the regulation of blood flow. Adenosine is a well known vasodilator that also acts as a modulator of the response to other vasoactive substances. Adenosine exerts its effects by interacting with adenosine receptors. These are metabotropic G-protein coupled receptors and include four subtypes, A1, A2A, A2B and A3. Adenosine triphosphate (ATP) is a co-transmitter in vascular neuroeffector junctions and is known to activate two distinct types of P2 receptors, P2X (ionotropic) and P2Y (metabotropic). ATP can exert either vasoconstrictive or vasorelaxant effects, depending on the P2 receptor subtype involved. Splanchnic vascular beds are of particular interest, as they receive a large fraction of the cardiac output. This review focus on purinergic receptors role in the splanchnic vasomotor control. Here, we give an overview on the distribution and diversity of effects of purinergic receptors in splanchnic vessels. Pre- and post-junctional receptormediated responses are summarized. Attention is also given to the interactions between purinergic receptors and other receptors in the splanchnic circulation. <br> <br> Keywords: Adenosine receptors, purinergic, P2X receptors, P2Y receptors, Splanchnic vasculature <br> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486341/?report=abstract"> Texto integral </a> <br> <br>

Abstract (EN): There is considerable evidence that purines are vasoactive molecules involved in the regulation of blood flow. Adenosine is a well known vasodilator that also acts as a modulator of the response to other vasoactive substances. Adenosine exerts its effects by interacting with adenosine receptors. These are metabotropic G-protein coupled receptors and include four subtypes, A1, A2A, A2B and A3. Adenosine triphosphate (ATP) is a co-transmitter in vascular neuroeffector junctions and is known to activate two distinct types of P2 receptors, P2X (ionotropic) and P2Y (metabotropic). ATP can exert either vasoconstrictive or vasorelaxant effects, depending on the P2 receptor subtype involved. Splanchnic vascular beds are of particular interest, as they receive a large fraction of the cardiac output. This review focus on purinergic receptors role in the splanchnic vasomotor control. Here, we give an overview on the distribution and diversity of effects of purinergic receptors in splanchnic vessels. Pre- and post-junctional receptormediated responses are summarized. Attention is also given to the interactions between purinergic receptors and other receptors in the splanchnic circulation. <br> <br> Keywords: Adenosine receptors, purinergic, P2X receptors, P2Y receptors, Splanchnic vasculature <br> <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486341/?report=abstract"> Full text </a> <br> <br>

Idioma: Inglês

Tipo (Avaliação Docente): Científica