The hemodynamics conditioned by coronary geometry may play an important role in the creation of a pro-atherogenic environment in specific locations of the coronary tree. The aim of this study is to identify how several geometric parameters of the left coronary artery - cross-section areas, proximal left anterior descending artery length, angles between the branches and the septum, curvature and tortuosity - can be related with hemodynamic descriptors, using a computational fluid-structure interaction method. It is widely accepted that the hemodynamic indicators play an important role in identifying possible pro-atherogenic locations. A statistical study, using Pearson correlation coefficient and P value, was performed for a population study of 8 normal human left coronary arteries presenting right-dominant circulation. Within the study cases, arteries with high caliber (r=0.88), high angles (LMS-LAD) (r=0.49), (LAD-LCx) (r=0.57) and (LAD-Septum) (r=0.52), and high tortuosity (LMS-LCx) (r=0.63) were correlated with a hemodynamic behavior propitious to plaque formation in the left anterior descending artery. In contrast, high proximal left anterior descending artery length (r=-0.41), high angle (LMS-LCx) (r=-0.59), high tortuosity (LMS-LAD) (r=-0.56) and (LAD-LCx) (r=-0.55) and high curvature of LMS (r=-0.60) and LCx (r=-0.56) can lead to non-favorable hemodynamic conditions for atheroma formation.
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