Immunohistochemical Characterization of 13 Canine Renal Cell Carcinomas

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

R. M. Gil da Costa (Autor) FEUP; J. P. Oliveira (Autor) Outra; A. L. Saraiva (Autor) Outra; F. Seixas (Autor) Outra; F. Faria (Autor) Outra; F. Gäertner (Autor) Outra; M. A. Pires (Autor) Outra; C. Lopes (Autor) Outra

Revista

Título: Veterinary Pathology

Vol. 48 Nº 2

Páginas: 427-432

ISSN: 0300-9858

Editora: SAGE

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 12 Citações

Outras Informações

ID Authenticus: P-002-TGM

DOI: 10.1177/0300985810381909

Abstract (EN): Canine renal cell carcinomas (RCCs) are uncommon aggressive tumors that occur mainly in middle-aged male dogs. Their histologic classification bears no relationship with prognosis, and little information is available concerning their immunohistochemical properties. In this retrospective study, formalin-fixed, paraffin-embedded tissues from 13 canine RCCs were retrieved from the archives, classified histologically, and evaluated immunohistochemically. The dogs were 7 males and 6 females (1 spayed) of 10 different breeds, averaging 8 years in age. The tumors were classified as papillary, tubulopapillary, papillary-cystic, solid, or sarcomatoid. All 13 tumors were immunohistochemically positive for uromodulin, 12 for c-KIT, 11 for vimentin, 9 for wide-spectrum-screening cytokeratins, 7 for cytokeratins AE1/AE3 and carcinoembryonic antigen, 4 for cytokeratins CAM 5.2, and 3 for CD10. All 3 solid RCCs expressed vimentin, c-KIT, and carcinoembryonic antigen and were negative for cytokeratins. All 7 papillary and tubulopapillary tumors expressed vimentin; 6 (86%), cytokeratins; and 6 (86%), c-KIT. Both papillary-cystic RCCs were positive for cytokeratins and c-KIT and negative for vimentin. These results indicate that the different histologic types of RCC have characteristic immunohistochemical profiles and that c-KIT may be involved in the pathogenesis of canine RCC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6