Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Sofia Sousa Fernandes (Autor) Outra; Ana Nunes (Autor) Outra; Ana Rita Gomes (Autor) Outra; Baltazar de Castro (Autor) FCUP; Robert C Hider (Autor) Outra; Maria Rangel (Autor) ICBAS; Rui Appelberg (Autor) ICBAS; Maria Salome Gomes (Autor) ICBAS

Revista

Título: Microbes and Infection

Vol. 12

Páginas: 287-294

ISSN: 1286-4579

Editora: Elsevier

Indexação

ISI Web of Knowledge - 41 Citações

Scopus - 40 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências Médicas

Outras Informações

ID Authenticus: P-003-81K

DOI: 10.1016/j.micinf.2010.01.003

Abstract (EN): Iron accumulation has been suggested to contribute to an increase of the susceptibility to mycobacterial infections. In this study we tested the effect of an array of iron chelating ligands of the 3-hydroxy-4-pyidinone family, in the intramacrophagic growth of Mycobacterium ovum, We found that bidentate chelators, namely N-alkyl-3-hydroxy-4-pyrichnones and N-aryl-3-hydroxy-4-pyndinones, did not affect the growth of M avium inside mouse macrophages In the case of the hexadentate chelators, those synthesized using an alkylamine (CP262) or a benzene ring (CP252) to link the three bidentate units, did not have an inhibitory effect on intramacrophagic growth of M (mum while those synthesized from a tripodal structure to anchor the bidentate units were capable of inhibiting the intramacrophagic growth of M. (MUM The molecule we designated CP777 had the strongest inhibitory activity The growth-reducing activity of CP777 was abrogated when this molecule was saturated with iron These results confirm that iron deprivation, by the use of iron chelating compounds, restricts M ovum growth and that new iron chelators offer an approach to controlling mycobacterial infections

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8