A Real-World Study Reporting the Use of Foundation Medicine® Testing in Portugal

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Pinto, R (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: JOURNAL OF MOLECULAR PATHOLOGY

Vol. 4

Páginas: 156-165

ISSN: 2673-5261

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-010-481

DOI: 10.3390/jmp4030014

Abstract (EN): Foundation Medicine (R) testing is a next-generation sequence (NGS)-based platform that allows clinicians to obtain the comprehensive genomic profiling (CGP) of several cancers. By using NGS approaches, relevant genomic alterations can be identified in a short timeframe, providing guidance to diagnostic and therapeutic decisions. This study reports the implementation of three commercially available Foundation Medicine (R) tests in a Portuguese institution and explores the genomic alterations identified. Data obtained from 72 patients tested with Foundation Medicine (R) between July 2017 and December 2020 were analysed retrospectively. A total of 290 gene alterations were identified, and TP53 was the gene most frequently altered. Among the 67 successfully profiled samples, 37.3% presented a potentially actionable variation. Breast carcinoma represented the most frequent tumour-carrying variation that can be targeted using currently approved drugs. A limited number of potentially actionable variants using approved drugs was found in this study; however, the genomic information provided by Foundation Medicine (R) may help clinicians in directing cancer patients into clinical trials or to off-label treatments.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10