Follicular thyroid carcinoma: Chromosome analysis of 19 cases

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Rogue, L (Autor) Outra; Clode, A (Autor) Outra; Belge, G (Autor) Outra; Pinto, A (Autor) Outra; Bartnitzke, S (Autor) Outra; Santos, JR (Autor) Outra; Thode, B (Autor) Outra; Bullerdiek, J (Autor) Outra; CASTEDO, S (Autor) FMUP; Soares, J (Autor) Outra

Revista

Título: Genes Chromosomes and Cancer

Vol. 21

Páginas: 250-255

ISSN: 1045-2257

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 27 Citações

Scopus - 30 Citações

Outras Informações

ID Authenticus: P-001-8BN

DOI: 10.1002/(

Abstract (EN): Short-term cultures of 19 follicular thyroid carcinomas were examined cytogenetically. Clonal chromosomal changes were detected in 12 tumors. Two follicular carcinomas had only numerical alterations: one with a hyperdiploid karyotype with trisomies/polysomies of chromosomes 7 and 12, similar to the karyotypes previously identified in a sub-group of benign thyroid lesions, and the other with monosomy 20. In the remaining ten cases several structural chromosome anomalies were found. Loss of the short arm of chromosome 3 was observed in one tumor. In two widely invasive and metastasizing follicular carcinomas there was a t(7;8)(p 15;q24) as the sole abnormality in one case and a der(8)t(7;8)(p 15;q24) together with other cytogenetic alterations in the other case. This finding suggests that t(7;8)(p 15;q24) may be related to an aggressive behavior of follicular thyroid carcinomas. (C) 1998 Wiley-Liss, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6