Ovarian Leydig cell tumor in a post-menopausal patient with severe hyperandrogenism

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Souto, SB (Autor) Outra; Baptista, PV (Autor) Outra; Braga, DC (Autor) Outra; Carvalho, Davide (Autor) FMUP

Revista

Título: Arquivos Brasileiros de Endocrinologia e Metabologia

Vol. 58

Páginas: 68-70

ISSN: 0004-2730

Editora: Universidade de São Paulo

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 20 Citações

Outras Informações

ID Authenticus: P-009-J05

DOI: 10.1590/0004-2730000002461

Abstract (EN): Leydig cell tumors are rare ovarian steroid cell neoplasms. More than 75% of patients show signs of virilization due to overproduction of testosterone. We report a case of an 8-year-old woman with progressive signs of virilization, and presenting vaginal bleeding. Clinical analyses revealed high levels of serum testosterone, delta 4-androstenedione and estradiol, and also inappropriate low levels of gonadotrophins for a post-menopausal woman. Transvaginal ultrasound showed no evidence of ovarian tumor, but pelvic and abdominal computerized axial tomography imaging revealed a left ovarian solid nodule, and no evidence of alteration in the adrenal glands. Total hysterectomy and bilateral salpingoophorectomy were performed. Histopathology and immunohistochemistry confirmed the diagnosis of Leydig cell tumor. After surgery, androgen levels returned to normal, and there was regression of the signs of virilization.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3