Computational Insight into Anti-mutagenic Properties of CYP1A Flavonoid Ligands

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Rute da Fonseca (Autor) Outra; Michele Marini (Autor) Outra; Andre Melo (Autor) FCUP; Maria Cristina Menziani (Autor) Outra; Maria Joao Ramos (Autor) FCUP

Revista

Título: Medicinal Chemistry

Vol. 1

Páginas: 355-360

ISSN: 1573-4064

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-35D

DOI: 10.2174/1573406054368729

Abstract (EN): Cytochrome P450 1A (CYP1A) is a subclass of enzymes involved in the biotransformation of heterocyclic amines present in cooked red meat to carcinogenic compounds. Anti-cancer properties have long been associated with flavonoids, and some compounds of this class have been shown to interact directly with CYP1A2. The understanding of this interaction is the purpose of this work. As the number of experimentally tested molecules is limited, two complementary methods in terms of information provided, are proposed for the study of protein-inhibitor interaction as alternatives to a QSAR analysis, using quantum mechanics as well as molecular mechanics.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6