Molecular Therapies

Code:

OPT31

Acronym:

TM14

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2021/2022 - 1S (of 13-09-2021 to 13-02-2022)

Active?	No
Responsible unit:	Departamento de Biomedicina
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	0	Plano Oficial 2021	3	-	2	19	54

Teaching language

Suitable for English-speaking students

Objectives

Knowledge of the scientific background of some of the current molecular therapies available in the basic and clinical setting

Develop the skills to define the scientific basis of molecular therapies based on the knowledge of the diseases in order to define the clinial applications of these techniques. Critical understanding of scientific and ethic limitations of molecular therapies.

Background to the  basic rules about the proposal of scientific projects.

Ability for oral presentation.

Work in small groups.

Ability to writte according to scientific rules.

Learning outcomes and competences

The syllabus is organized to reflect the current applications of molecular therapies in order to provide a critical knowledge of the Basic and clinical applications of molecular therapies. The curricular Unit is proposed in the first semester of the 3rd year so that the students have a clear knowledge of molecular biology techniques and the rudiment information about several pathologies which can benefit from the aplication of molecular therapies.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

The curricular Unit is proposed in the first semester of the 3rd year so that the students have a clear knowledge of molecular biology and immunology acquired during the 1st and 2nd year of the curriculum. Additionally, the students must know the rudiment information about several pathologies which can benefit from the aplication of molecular therapies.

Program

Molecular therapies: definition and types. Legislation.

Gene therapy: general principles and main clinical applications. Clinical trials in inherited diseases.

Design and construction of vectors (viral and non-viral). Directing vectors.

Post-transcriptional therapies: antisense oligonucleotides and RNAi.

Antibody therapies: genral principles and mains clinical applications

Cell therapies: stem cells

Nanobiomaterials in molecular therapies

Mandatory literature

David Whitehouse & Ralph Rapley (Eds.); Molecular and Cellular Therapeutics. 2012. ISBN: 978-1-1199-6780-4

Teaching methods and learning activities

Classes, work group.

Type of evaluation: Presentation of a scientific project using molecular therapies

Terms of frequency: Presence in the minimum of classes defined by the Regulamento Pedagógico of FMUP

Formula Evaluation: 50% for oral presentation; 50% for written work

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation	Weight (%)
Defesa pública de dissertação, de relatório de projeto ou estágio, ou de tese	50,00
Trabalho escrito	50,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Elaboração de projeto	35,00
Frequência das aulas	19,00
Total:	54,00

Eligibility for exams

Terms of frequency: Presence in the minimum of classes defined by the Regulamento Pedagógico of FMUP

Calculation formula of final grade

Formula Evaluation: 50% for oral presentation; 50% for written work