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Gerontologia I

Code: MMOM13_10     Acronym: Gerontologia

Classification Keyword
OFICIAL Medical and Molecular Oncology

Instance: 2021/2022 - SP (of 13-09-2021 to 15-07-2022) Ícone do Moodle

Active? Yes
Responsible unit: Departamento de Biomedicina
Course/CS Responsible: Molecular Medicine and Oncology

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MMOM 9 Plano Oficial do ano letivo 2018 1 - 3 21 81

Teaching Staff - Responsibilities

Teacher Responsibility
Delminda Rosa Gamelas Neves Lopes de Magalhães
Henrique Manuel Nunes de Almeida

Teaching language

Portuguese and english
Obs.: Português (ou inglês, se houver docentes ou estudantes que não falem português)


To acquire basic knowledge on the ageing process, particularly its likely causes and intervening mechanisms.

To learn key-concepts of gerontology, historical aspects of the subject, its evolution and the curent frontiers, with the help of internationally recognized scientists.

To set forth scientific problems of the field and methodological strategies to solve them.

To understand the current experimental models of ageing, with emphasis on cell models.

Learning outcomes and competences

Perception of the current biological frontier in Gerontology. 

Understanding and integration of biological mechanisms and experimental models of ageing.

Recognition, by direct contact, of the role of the laboratory in the study of biogerontology.

Capacity to enunciate biological problems in gerontology and to organize a strategy to their resolution.

Ability to analyze scientific literature in the fielf of gerontology.

Working method



Ageing overview. Key concepts, causes and mechanisms.
The essence of ageing: progressive molecular and celular lesions.
The role of telomeres. Cell repairing processes, with emphasis on mechanisms of DNA and protein repair.
Models and methods in cell ageing: Hayflick and Stress Induced Premature Senescence (SIPS) models. The study of organism ageing.
The role of nutrition and metabolism. Energy restriction.
The role of genes. Survival pathways and hormesis.
Biological aspects of human, or mammalian, ageing in different organ or systems.
To prolong life or to mitigate ageing.
The SIPS model of cell ageing. How to establish it in the laboratory.
Accelerated ageing: biological foundation.

Mandatory literature

Roger B McDonald; Biology of Aging

Comments from the literature

The recommended is introductory to the field. Addictional publications for further study and discussion in sessions, will be provided in due time.

Teaching methods and learning activities

Lectures, seminars, paper review and discussion, laboratiry sessions.


Health sciences
Natural sciences > Biological sciences > Biology > Human biology
Natural sciences > Biological sciences > Biology > Cell biology

Evaluation Type

Evaluation with final exam

Assessment Components

Designation Weight (%)
Teste 100,00
Total: 100,00

Amount of time allocated to each course unit

Designation Time (hours)
Estudo autónomo 60,00
Frequência das aulas 21,00
Total: 81,00

Eligibility for exams

Present in 75% of sessions

Calculation formula of final grade

Without formula


According to student´s number, evaluation may be by preparing an essay.
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