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Code: PD_MCE010     Acronym: PD_MCE010

Classification Keyword
OFICIAL Medicine

Instance: 2021/2022 - SP (of 13-09-2021 to 31-07-2022) Ícone do Moodle

Active? Yes
Responsible unit: Departamento de Biomedicina
Course/CS Responsible: PhD in Metabolism - Clinical and Experimental

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
PDMCE 7 Plano Oficial do ano letivo 2019 1 - 3 12 81

Teaching language

Obs.: Português e ingles


To understand the molecular mechanisms and the main factors involved in angiogenesis, as well as the angiogenic modulators (hypoxia, inflammation, oxidative stress, hormones, etc). To identify the role of angiogenesis in physiological and distinct pathological situations. To recognize methodologies used for examining angiogenesis (in vitro and in vivo models). To identify pro- and anti-angiogenic therapies.


The angiogenesis as a multistep process; processes that mediate angiogenesis, such as hypoxia, inflammation, oxidative stress, hormones, etc; the molecular mechanisms implicated, autocrine, paracrine and endocrine interactions involved in this process; and angiogenic imbalance in pathological situations, including cancer, diabetes and its vascular complications, cardiovascular disease. The role of radiotherapy in angiogenesis will be discussed. Pro- and anti-angiogenic therapies in clinical use will also be identified.

Learning outcomes and competences

The students are expected to obtain theoretical competencies and identify methodologies regarding the evaluation of angiogenesis in pathological situations. For example, to acknowledge angiogenesis as a multistep process;  angiogenic modulators, including hypoxia and inflammation, molecular mechanisms; autocrine, paracrine and endocrine interactions implicated in angiogenesis, and angiogenic imbalance in distinct  pathological conditions, such as cancer, diabetes, diabetic retinopathy, age-related macular degeneration, stroke and cardiovascular diseases. The role of radiotherapy in angiogenesis will be discussed. Pro- and antiangiogenic therapies used in the clinic will be described.

Working method


Pre-requirements (prior knowledge) and co-requirements (common knowledge)



Introduction. Mechanisms of vascularization and signaling pathways

Angiogenic modulators: hypoxia; Inflammation

Methodologies for angiogenesis evaluation in vitro and in vivo

Pathological angiogenesis: a) Diabetic retinopathy, Retinopathy of the prematurity, AMD; b) Solid tumors c) Angiogenesis and radiotherapy; d) stroke

Angigoenesis and tissue regeneration

Anti-angiogenic and pro-angiogenic therapies

Mandatory literature

Soares R. ; Angiogenesis in metabolic syndrome. In: Oxidative stress, inflammation and angiogenesis in metabolic syndrome., 2009
Eelen G, de Zeeuw P, Simons M, Carmeliet P.; Endothelial Cell Metabolism in Normal and Diseased Vasculature. , 2015
CostaC, Incio J, Soares R; Angiogenesis and Inflammation.cause or Consequence?, Angiodenesis, 2007. ISBN: 10:149-66
Carneiro A,Costa R, Falcao M,Mendonça L, Fonseca S, Gonçalves R, Falco-Reis, Soares R; Vascular endothelial growth factor levels before and after treatment of neovascular age-related macular, Acta Ophthalmol , 2012

Complementary Bibliography

Cao Y, Langer R. ; A review of Judah Folkman's remarkable achievements in biomedicine. , 2008

Teaching methods and learning activities

Lectures, topics discussion with students.

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation Weight (%)
Participação presencial 20,00
Trabalho prático ou de projeto 80,00
Total: 100,00

Amount of time allocated to each course unit

Designation Time (hours)
Frequência das aulas 12,00
Total: 12,00

Eligibility for exams

Presence in 75% of the classes

Calculation formula of final grade

NF (Final mark) = 0.80* written work + 0.20* participation in the classes

Examinations or Special Assignments


Internship work/project


Special assessment (TE, DA, ...)


Classification improvement

A second written work (monography) or a project regarding a topic related to angiogenesis (chosen by the student).


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