Transmembrane transport and human physiopathology

Code:

OPT181

Acronym:

TTFH

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2019/2020 - 1S (of 09-09-2019 to 09-02-2020)

Active?	Yes
Responsible unit:	Departamento de Biomedicina
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	11	Mestrado Integrado em Medicina- Plano oficial 2013 (Reforma Curricular)	2	-	1,5	13	40,5
			3

Teaching language

Portuguese and english
Obs.: Português

Objectives

Knowledge on the mechanisms involved in the transport of solutes across biological membranes. Knowledge on the characteristics of specific transport mechanisms, relevant in medicine: involvement of alterations of transport mechanisms in the physiopathology of some diseases, the consequences of pathologies in the transmembranar transport, changes in transport mechanisms in cancer cells, the influence of transmembranar transport in therapeutics. Acquisition of skills in writing of a review article and presenting a scientific paper.

Learning outcomes and competences

Knowledge on the mechanisms involved in the transport of solutes across biological membranes. Knowledge on the characteristics of specific transport mechanisms, relevant in medicine: involvement of alterations of transport mechanisms in the physiopathology of some diseases, the consequences of pathologies in the transmembranar transport, changes in transport mechanisms in cancer cells, the influence of transmembranar transport in therapeutics. Acquisition of skills in writing of a review article and presenting a scientific paper.

Working method

Presencial

Program

The transmembranar transport of solutes in humans

The intestinal transport of some bioactive compounds

Transport of nutrients in the placenta

Alterations in transport and intestinal pathologies

Transport of dopamine and addiction

Multidrug Resistance

Alterations of transmembranar transport in hypertension

Transport of butyrate and colorectal cancer

Effect of polyphenols in nutrient transport: relevance for cancer and metabolic syndrome

Na+/K+ ATPase

TRPV1 and human pathology

Mandatory literature

Petzinger E, Geyer J. ; Drug transporters in pharmacokinetics.
Moraes TF, Reithmeier RAF; Membrane transport metabolons
Lee AG. ; Biological membranes: the importance of molecular detail.
Terada T, Inui K-I. ; Gene expression and regulation of drug transporters in the intestine and kidney.
Gether U, Andersen PH, Larsson OM and Schousboe A. ; Neurotransmitter transporters: molecular function of important drug targets.
Christopher J. Endres CJ, Hsiao P, Chung FS, Unadkat JD. ; The role of transporters in drug interactions.

Teaching methods and learning activities

Methodologies:

-Theoretical classes

-Journal club (presentation of scientific papers by the students)

 -Writiting of a review paper on a theme related to “Transmembranar transportand human pathophysiology” 

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation	Weight (%)
Apresentação/discussão de um trabalho científico	50,00
Trabalho escrito	50,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	27,50
Frequência das aulas	13,00
Total:	40,50

Eligibility for exams

Obtained when the total of hours missed is not superior to 25% of the total hours of the unit; apresentation of the journal club is mandatory.

Calculation formula of final grade

Evaluation:

-Writiting of a review paper on a theme related to “Transmembranar transport and human pathophysiology” (50%) and presentation of a scientific article in the Journal Club (50%)