Reprogramming stem cells and carcinogenesis

Code:

OPT29

Acronym:

RCEC

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2017/2018 - 2S

Active?	Yes
Responsible unit:	Departamento de Patologia
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	23	Mestrado Integrado em Medicina- Plano oficial 2013 (Reforma Curricular)	2	-	1,5	14	40,5
			3

Teaching language

Suitable for English-speaking students

Objectives

1. To identify the main features of neoplasias.


2. To distinguish embryonic stem cells, adult stem cells and iPS cells.


3. To relate regeneration, transdifferentiation and metaplasia.


4. To identify the pathological conditions in which they occur.


5. To understand an example of a pathological condition where regeneration and transdifferentiation predispose to cancer.


6. To identify other regenerative conditions.


7. To identify preneoplastic lesions, regenerative and with transdifferentiation through histological and immunohistochemical observation.


8. To identify the concept of cancer stem cells.


9. To discuss what are the potential applications of stem cells for tissue regeneration, in reference to Regenerative Medicine.

Learning outcomes and competences

The curricular unit includes topics intended at the understanding of how regenerative conditions as well as stem cell reprogramming predispose to cancer, using different examples both in human pathological situations and in animal models. To better understand these mechanisms, topics focusing on basic aspects of stem cell biology and the state of the art on stem cell reprogramming in the context of regenerative medicine were included. The discussion of how this reprogramming leads to cancer will be promoted through the presentation of articles published in peer-reviewed journals. The theoretical part will be complemented by a practical class in which the pathological conditions under study will be visualized under the microscope.

Working method

Presencial

Program

Introduction to oncobiology.

Stem cells and tissue homeostasis.

Regeneration, transdifferentiation and metaplasia.

Cellular reprogramming and carcinogenesis.

Examples of pathological conditions that harbour some or all of these processes.

Intestinal metaplasia: an example of a regenerative condition, with transdifferentiation that predisposes to cancer.

Cancer stem cells.

Stem cell therapies.

Mandatory literature

Robbins and Conan ; Pathologic basis of disease

Teaching methods and learning activities

Lectures and Seminars

Evaluation: Written exam - Test with multiple-choice questions and short answer questions

Evaluation Type

Evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Calculation formula of final grade

The final classification will be the one obtained in the exam.