Invasive in Vivo Evaluation of Cardiac Function II
Keywords |
Classification |
Keyword |
OFICIAL |
Medicine |
Instance: 2015/2016 - 2S
Cycles of Study/Courses
Acronym |
No. of Students |
Study Plan |
Curricular Years |
Credits UCN |
Credits ECTS |
Contact hours |
Total Time |
MFC |
8 |
Current Studies Plan |
1 |
- |
3 |
27 |
81 |
Teaching Staff - Responsibilities
Teaching - Hours
Type |
Teacher |
Classes |
Hour |
Theoretical classes |
Totals |
1 |
0,64 |
Daniel Moreira Goncalves |
|
0,07 |
André Pedro Leite Martins Lourenço |
|
0,32 |
Inês Maria Falcão Sousa Pires Marques |
|
0,25 |
Theoretical and practical |
Totals |
1 |
0,28 |
Inês Maria Falcão Sousa Pires Marques |
|
0,07 |
Daniel Moreira Goncalves |
|
0,07 |
André Pedro Leite Martins Lourenço |
|
0,14 |
Laboratory Practice |
Totals |
3 |
3,00 |
Inês Maria Falcão Sousa Pires Marques |
|
0,36 |
André Pedro Leite Martins Lourenço |
|
0,50 |
Daniel Moreira Goncalves |
|
0,14 |
Teaching language
Suitable for English-speaking students
Objectives
Students will be taught the main evaluation methodologies, including simple evaluation of ventricular pressure and joint assessment of pressure and volume, including the advantages and disadvantages of each of the approaches.
Learning outcomes and competences
Students are expect to: Understand the main methodologies for assessment of ventricular function in vivo, as well as the indices of ventricular systolic and diastolic function. Understand the representation of the cardiac cycle by pressure-volume loop and the role played by changes in pre-load, after-load, contractility and compliance. Understand the characterization of ventricular systolic and diastolic properties from end-systolic and and-diastolic pressure-volume relationships. Understand and interpret changes in cardiovascular pathology. Interpret clinical cases.
Working method
Presencial
Program
Methodologies for evaluating ventricular volumes in real time: sono-micrometry, conductance and admittance. Advantages and disadvantages of each of them. Systolic and diastolic function indexes obtained by analysis of the pressure tracing. Relaxation rates: various methodologies for calculation of the isovolumetric time constant (tau). Dependence of load. Joint analysis of variations of ventricular pressure and volume throughout the cardiac cycle. Influence of load, contractility and compliance. Transient variations of load to obtain robust and independent indices of contractility and filling capacity. Changes in cardiovascular pathology: heart failure with reduced ejection fraction and heart failure with preserved ejection fraction. Analysis and interpretation of clinical cases.
Mandatory literature
Pacher, P., Nagayama, T., Mukhopadhyay, P., Batkai, S., & Kass, D. A. ; Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats. , Nat Protoc, 3(9), 1422-1434. doi: 10.1038/nprot.2008.138, 2008
Kottam, A. T., Porterfield, J., Raghavan, K., Fernandez, D., Feldman, M. D., Valvano, J. W., & Pearce, J. A. ; Real time pressure-volume loops in mice using complex admittance: measurement and implications. , Conf Proc IEEE En, 2006
Lourenço, A., Falcão-Pires, I., & Leite-Moreira, A. ; In Vivo Experimental Assessment of Cardiac Function. In D. V. Cokkinos (Ed.), Introduction to Translational Cardiovascular Research, Springer International Publishing (pp. 389-411), 2014
Tulner, S. A., et al.; Perioperative assessment of left ventricular function by pressure-volume loops using the conductance catheter method. , Anesth Analg, 97(4), 950-957, 2003
Teaching methods and learning activities
Theoretical sessions in which the contents will be explained. Practical sessions in which pupils can practice in animal models the acquisition of pressure and ventricular volume recordings and subsequently analyse these recordings. Pathology cases or tracings obtained from animal models of disease will be discussed.
Evaluation Type
Distributed evaluation with final exam
Assessment Components
Designation |
Weight (%) |
Exame |
50,00 |
Trabalho laboratorial |
50,00 |
Total: |
100,00 |
Calculation formula of final grade
Theoretical evaluation of content (50%) and evaluation of participation in practice sessions (50%).