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Invasive in Vivo Evaluation of Cardiac Function II

Code: MFC27     Acronym: AvInvCarII

Classification Keyword
OFICIAL Medicine

Instance: 2015/2016 - 2S Ícone do Moodle

Active? Yes
Responsible unit: Physiology and Cardiothoracic Surgery Department
Course/CS Responsible: Master Degree Course in Cardiovascular Pathophysiology

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MFC 8 Mestrado em Fisiopatologia Cardiovascular_2013 1 - 3 27 81

Teaching Staff - Responsibilities

Teacher Responsibility
André Pedro Leite Martins Lourenço

Teaching language

Suitable for English-speaking students


Students will be taught the main evaluation methodologies, including simple evaluation of ventricular pressure and joint assessment of pressure and volume, including the advantages and disadvantages of each of the approaches.

Learning outcomes and competences

Students are expect to: Understand the main methodologies for assessment of ventricular function in vivo, as well as the indices of ventricular systolic and diastolic function. Understand the representation of the cardiac cycle by pressure-volume loop and the role played by changes in pre-load, after-load, contractility and compliance. Understand the characterization of ventricular systolic and diastolic properties from end-systolic and and-diastolic pressure-volume relationships. Understand and interpret changes in cardiovascular pathology. Interpret clinical cases.

Working method



Methodologies for evaluating ventricular volumes in real time: sono-micrometry, conductance and admittance. Advantages and disadvantages of each of them. Systolic and diastolic function indexes obtained by analysis of the pressure tracing. Relaxation rates: various methodologies for calculation of the isovolumetric time constant (tau). Dependence of load. Joint analysis of variations of ventricular pressure and volume throughout the cardiac cycle. Influence of load, contractility and compliance. Transient variations of load to obtain robust and independent indices of contractility and filling capacity. Changes in cardiovascular pathology: heart failure with reduced ejection fraction and heart failure with preserved ejection fraction. Analysis and interpretation of clinical cases.

Mandatory literature

Pacher, P., Nagayama, T., Mukhopadhyay, P., Batkai, S., & Kass, D. A. ; Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats. , Nat Protoc, 3(9), 1422-1434. doi: 10.1038/nprot.2008.138, 2008
Kottam, A. T., Porterfield, J., Raghavan, K., Fernandez, D., Feldman, M. D., Valvano, J. W., & Pearce, J. A. ; Real time pressure-volume loops in mice using complex admittance: measurement and implications. , Conf Proc IEEE En, 2006
Lourenço, A., Falcão-Pires, I., & Leite-Moreira, A. ; In Vivo Experimental Assessment of Cardiac Function. In D. V. Cokkinos (Ed.), Introduction to Translational Cardiovascular Research, Springer International Publishing (pp. 389-411), 2014
Tulner, S. A., et al.; Perioperative assessment of left ventricular function by pressure-volume loops using the conductance catheter method. , Anesth Analg, 97(4), 950-957, 2003

Teaching methods and learning activities

Theoretical sessions in which the contents will be explained. Practical sessions in which pupils can practice in animal models the acquisition of pressure and ventricular volume recordings and subsequently analyse these recordings. Pathology cases or tracings obtained from animal models of disease will be discussed.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation Weight (%)
Exame 50,00
Trabalho laboratorial 50,00
Total: 100,00

Calculation formula of final grade

Theoretical evaluation of content (50%) and evaluation of participation in practice sessions (50%).
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