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Molecular Mechanisms in Heart Failure

Code: MFC26     Acronym: MecMolICard

Classification Keyword
OFICIAL Medicine

Instance: 2015/2016 - 2S Ícone do Moodle

Active? Yes
Responsible unit: Physiology and Cardiothoracic Surgery Department
Course/CS Responsible: Master Degree Course in Cardiovascular Pathophysiology

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MFC 9 Mestrado em Fisiopatologia Cardiovascular_2013 1 - 3 27 81

Teaching Staff - Responsibilities

Teacher Responsibility
Carmen Dulce da Silveira Brás Silva Ribeiro

Teaching language

Suitable for English-speaking students


This curricular unit will allow the students to obtain knowledge in emergent topics related with the pathophysiology of heart failure, particularly the involved molecular mechanisms and their therepeutic implications.

Learning outcomes and competences

This curricular unit has a learning objectives the knowledge of: the patophysiology of heart failure, in particular of the molecular mechanisms involved and (ii) of the therapeutic implications of the knowledge of these molecular pathways.

Working method



  1. Pathophysiology of heart failure

  2. Role of microRNAs in the pathophysiology of heart failure

  3. Natriuretic peptide role in the pathophysiology of heart failure

  4. Obesity and cachexia in heart filure progression

  5. Endothelial dysfunction in heart failure

  6. Infammatory mechanisms in heart failure progression

  7. pathophysiology of right heart failure - molecular mechanisms

  8. Pulmonary hypertension - molecular mechanisms

  9. Isquemic cardiomyopathy - molecular mechanisms

  10. Renin-angiotensin-aldosterone system in heart failure

Mandatory literature

Katz, A. M., & Konstam, M. A. ; Heart failure: pathophysiology, molecular biology, and clinical management., Lippincott Williams & Wilkins, 2012

Comments from the literature

Scientific articles selected by teachers.

Leite-Moreira, A. M., Lourenço, A. P., Falcão-Pires, I., & Leite-Moreira, A. F. (2013). Pivotal role of microRNAs in cardiac physiology and heart failure. Drug discovery today, 18(23), 1243-1249.

Mendes-Ferreira, P., De Keulenaer, G. W., Leite-Moreira, A. F., & Brás-Silva, C. (2013). Therapeutic potential of neuregulin-1 in cardiovascular disease. Drug discovery today, 18(17), 836-842.

Adão R, Santos-Ribeiro D, Rademaker MT, Leite-Moreira AF, Brás-Silva C. Urocortin 2 in cardiovascular health and disease. Drug Discov Today. 2015;20 (7): 906-14.

Tarone, G., Balligand, J. L., Bauersachs, J., Clerk, A., De Windt, L., Heymans, S., ... & Tocchetti, C. G. (2014). Targeting myocardial remodelling to develop novel therapies for heart failure. European journal of heart failure, 16(5), 494-508.

Teaching methods and learning activities

Theoretical, tutorial orientation and seminars

Evaluation Type

Evaluation with final exam

Assessment Components

Designation Weight (%)
Exame 100,00
Total: 100,00

Eligibility for exams

Attendance of at least 80% of all classes.

Calculation formula of final grade

Assessment: final exam (100%)
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