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Evaluation of cardiovascular function in vitro II

Code: MFC25     Acronym: AFuncCardiII

Classification Keyword
OFICIAL Medicine

Instance: 2015/2016 - 2S Ícone do Moodle

Active? Yes
Responsible unit: Physiology and Cardiothoracic Surgery Department
Course/CS Responsible: Master Degree Course in Cardiovascular Pathophysiology

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MFC 8 Mestrado em Fisiopatologia Cardiovascular_2013 1 - 6 54 162

Teaching Staff - Responsibilities

Teacher Responsibility
Carmen Dulce da Silveira Brás Silva Ribeiro
Mais informaçõesLast updated on 2015-10-26.

Fields changed: Calculation formula of final grade, Componentes de Avaliação e Ocupação, Tipo de avaliação

Teaching language

Suitable for English-speaking students


The main goal of this curricular unit is the acquisition of knowledge and training essential to prepare and interpretate the results obtained in the various models used to study the cardiac and smooth muscle function in rat and mouse models.

Learning outcomes and competences

Students are expect to acquire:

- skills for the setting up and monitoring of isolated cells or muscle preparations in organ baths.

- knowledge for the  interpretation of cardiac and smooth muscle function through the use of experimental models of isolated tissue a cells from rat and mouse.

Working method



Evaluation of cardiac and smooth muscle function in animal models of rat and mouse:

(i) Evaluation of the cardiac muscle function in isolated multicellular preparations;
(ii) Evaluation af cardiac muscle function in isolated cardiomyocytes;
(iii) Evaluation of isolated smooth muscle.

Mandatory literature

Gross, D. ; Animal models in cardiovascular research. , Springer Science & Business Media., 2009
Falcão- Pires, I., Leite-Moreira, AF. ; In vitro Experimental Assessment of Cardiac Function In D.V. Cokkinos (Ed.), Introduction to Translational Cardiovascular Research., Switzerland: Springer International Publishing, 371-387, 2014

Comments from the literature

Scientific articles selected by teachers.


Rocha-Sousa, A., Saraiva, J., Amaral, M., Alves-Faria, P., Falcão-Reis, F., & Leite-Moreira, A. F. (2009). ETB2 receptor subtype stimulation relaxes the iris sphincter muscle. Physiological Research, 58(6), 835.;

Leite-Moreira, A. F., & Brás-Silva, C. (2004). Inotropic effects of ETB receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins. American Journal of Physiology-Heart and Circulatory Physiology, 287(3), H1194-H1199.

Teaching methods and learning activities

Theoretical-pratical and laboratory work

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation Weight (%)
Exame 70,00
Trabalho escrito 15,00
Trabalho laboratorial 15,00
Total: 100,00

Eligibility for exams

Collection frequency: Attendance of at least 75% of all classes.

Calculation formula of final grade

Classification obtained in continuous assessment (30%) + Final Practical Evaluation (70%).

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