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Invasive in Vivo Evaluation of Cardiac Function I

Code: MFC19     Acronym: AvInvCardI

Classification Keyword
OFICIAL Medicine

Instance: 2015/2016 - 1S Ícone do Moodle

Active? Yes
Responsible unit: Physiology and Cardiothoracic Surgery Department
Course/CS Responsible: Master Degree Course in Cardiovascular Pathophysiology

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MFC 8 Mestrado em Fisiopatologia Cardiovascular_2013 1 - 3 27 81

Teaching Staff - Responsibilities

Teacher Responsibility
André Pedro Leite Martins Lourenço

Teaching language

Suitable for English-speaking students


Students will be informed about the main evaluation methodologies with a focus on their advantages and drawbacks, from the animal model to clinical practice.

Learning outcomes and competences

Students are expect to: Understand the basics of haemorheology and haemodynamics. Know in vivo hemodynamic evaluation methods in laboratory animal and human being. Understand the advantages and disadvantages of invasive evaluation. Know methodologies for determination of vascular/cardiac output flow. Understand the influence on evaluation of: (i) methods of anaesthesia/sedation, (ii) open and closed chest preparations, (iii) mechanical or spontaneous ventilation, (iv) ventricular interaction and, finally, (v) autonomic nervous system and neuroendocrine mediators. Critically analyse articles in this field of research.

Working method



Basic concepts on haemorheology and haemodynamics. Evaluation of pressure and flow at the vascular level: techniques and methodologies. Catheters and pressure transducers. Flow measurement: techniques and methodologies. Invasive and non-invasive evaluation. Experimental preparations with and without anaesthesia. Anaesthesia for invasive assessment methods and corresponding haemodynamic effects. Experimental preparations with open- chest and closed-chest. Influence of ventricular interaction and neuroendocrine systems. Interpretation of scientific works carried out in the area.

Mandatory literature

Cingolani, O. H., & Kass, D. A.; Pressure-volume relation analysis of mouse ventricular function., Am J Physiol Heart Circ Physiol; 301(6), H2198-2206, 2011
Burkhoff, D. ; Pressure-volume loops in clinical research: a contemporary view., J Am Coll Cardiol; 62(13), 1173-1176, 2013
Lourenço, A., Falcão-Pires, I., & Leite-Moreira, A. ; In Vivo Experimental Assessment of Cardiac Function. In D. V. Cokkinos (Ed.), Introduction to Translational Cardiovascular Research , Springer International Publishing; pp. 389-411, 2015
Burkhoff, D., Mirsky, I., & Suga, H. ; Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers, Am J Physiol Heart Circ Physiol, 289(2), H501-512. , 2005

Teaching methods and learning activities

Theoretical sessions in which the contents will be explained. Practical sessions in which pupils can find, empirically, in animal models, the concepts imparted in theoretical sessions. Reading and critical appraisal of scientific works carried out in the area.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation Weight (%)
Exame 50,00
Trabalho laboratorial 50,00
Total: 100,00

Calculation formula of final grade

Theoretical evaluation of content (50%) and evaluation of participation in practice sessions (50%).
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