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Evaluation of cardiovascular function in vitro I

Code: MFC18     Acronym: AvCardiovasc

Classification Keyword
OFICIAL Medicine

Instance: 2015/2016 - 1S Ícone do Moodle

Active? Yes
Responsible unit: Physiology and Cardiothoracic Surgery Department
Course/CS Responsible: Master Degree Course in Cardiovascular Pathophysiology

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MFC 8 Mestrado em Fisiopatologia Cardiovascular_2013 1 - 6 54 162

Teaching Staff - Responsibilities

Teacher Responsibility
Amândio António Rocha Dias de Sousa

Teaching language

Suitable for English-speaking students


This curricular unit embraces basic knowledge to mount and interpretate the various models od cardiac and vascular smooth muscle function.

Learning outcomes and competences

Students are expected to:

  1. Acquire the knowledge necessary to evaluate the cardiac and smooth muscle fuction using models of isolated rat and mice tissues (cardiac and smooth muslces tissues)
  2. To develop the skill to mount and monitorize muscular preprarations in organs bath setup

Working method



  1. Evaluation of the muscular heart funtion using isolated rat, mice cardiac muscles in organs bath

  2. Evaluation of the muscular vascular funtion using isolated rat and mice smooth muscles (vascular and non-vascular) in organs bath

  3. Experimental protocols in isolated rat and mice papilary muscles

  4. Experimental protocols in isolated rat and mice vascular smooth muscles

Mandatory literature

Brás-Silva, C. ; Miocárdicos da Endotelina-1 e suas implicações na Fisiopatologia da Insuficiência Cardíaca. (Tese de Doutoramento), 2006
Fontes-Sousa, AP. ; Mecanismos Neuro-Humorais e Endoteliais na Insuficiência Cardíaca. Implicações Fisiopatológicas e Terapêuticas. (Tese de Doutoramento), 2008
Leite-Moreira, AF. ; Relaxamento miocárdico normal e patológico. (Tese de Doutoramento, 1997
Rocha-Sousa, A. ; Regulação neuro-humoral da contracção dos elementos musculares da úvea e suas implicações fisiopatológicas. (Tese de Doutoramento), 2007
Sys, S. U., De Keulenaer, G. W., & Brutsaert, D. L. ; Physiopharmacological evaluation of myocardial performance how to study modulation by cardiac endothelium and related humoral factors?, Cardiovascular research, 39(1), 136-147, 1998

Teaching methods and learning activities

Teaching methods:

Tutorials (18 h) or tutorial  (5 h).

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation Weight (%)
Trabalho escrito 100,00
Total: 100,00

Calculation formula of final grade

Assessment: Distributed without exam
Collection frequency: Attendance of at least 80% of all classes.
Calculation of final grade: Classification obtained in continuous assessment
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