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Modelos Animais e Ecocardiografia Cardiovascular

Code: PDCCV13_11     Acronym: MAEC

Keywords
Classification Keyword
OFICIAL Medicine

Instance: 2015/2016 - 2S

Active? Yes
Responsible unit: Physiology and Cardiothoracic Surgery Department
Course/CS Responsible: Doctoral Programm in Cardiovascular Sciences

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
PDCCV 0 Ciências Cardiovasculares_13 1 - 3 13,5 81

Teaching Staff - Responsibilities

Teacher Responsibility
Tiago Alexandre Henriques Coelho

Teaching language

Suitable for English-speaking students

Objectives

This unit aims to give students a strong theoretical knowledge of experimental models that enable them to choose the model that best fits the research project that they will develop.

Learning outcomes and competences

Acquire knowledge on the different experimental models that simulate the major human cardiovascular syndromes. To discuss the advantages and disadvantages of the different models.

Acquire knowledge on the importance and application of echocardiography as a non-invasive imaging method to study cardiac (dys)function in animal experimentation. To recognize the most important echocardiography windows, as well as the reference parameters of two-dimensional, M-mode, conventional Doppler and tissue Doppler echocardiography.

Working method

Presencial

Program

Experimental Models:

- Doxurubicin;

- Monocrotaline;

- Anterior descendente coronary artery blockage-induced stroke;

- Aortic banding-induced pressure overload;

- Arterio-venous fistula-induced overload;

- Fast pacing-induced heart failure;

- Viral myocarditis;

- Transgenic;

Ecochardiography:

- Basic concepts of cardiac anatomy

- Morphologic criteria to identify cardiac chambers, auriculoventricular and sigmoid valves and major vessels;

- Definition of cardiac situs, cardiac spetation and segmental ordering;

- Historical view of echocardiography;

- Ultrasound wave and image production;

- Image quality and artifacts in experimental echocardiography;

- Equipment and probe types;

- Animal preparation and anesthetic care;

- Standard transthoracic echocardiography projections and adaptations to image acquisition in animals;

- Two-dimensional echocardiography; clinical applications;

- Doppler physical principles;

- Doppler types (pulsed, continuous, colour) and its characteristics

Mandatory literature

Xu, Q. ; A Handbook of Mouse Models of Cardiovascular Disease, Wiley, 2006
Horgan S, Watson C, Glezeva N, Baugh J. ; Murine models of diastolic dysfunction and heart failure with preserved ejection fraction. , J Card Fail. 20:984-95, 2014
Fiedler LR, Maifoshie E, Schneider MD. ; Mouse models of heart failure: cell signaling and cell survival. , Curr Top Dev Biol. 109:171-247, 2014
Guihaire J, Bogaard HJ, Flécher E, Noly PE, Mercier O, Haddad F, Fadel E. ; Experimental models of right heart failure: a window for translational research in pulmonary hypertension. , Semin Respir Crit Care Med. 34:689-99, 2013
Houser SR., et al; Animal models of heart failure: a scientific statement from the American Heart Association., Circ Res. 111:131-50, 2012
Abduch MC, Assad RS, Mathias W Jr, Aiello VD. ; The Echocardiography in the cardiovascular laboratory: a guide to research with animals., Arq Bras Cardiol. 102:97-103, 2014
Ram R, Mickelsen DM, Theodoropoulos C, Blaxall BC. ; New approaches in small animal echocardiography: imaging the sounds of silence., Am J Physiol Heart Circ Physiol. 301:H1765-80, 2011
Scherrer-Crosbie M, Thibault HB. ; Echocardiography in translational research: of mice and men. , J Am Soc Echocardiogr. 21:1083-92, 2008

Teaching methods and learning activities

Lectures; theoretical-practical and practical

Evaluation Type

Evaluation with final exam

Assessment Components

Designation Weight (%)
Exame 100,00
Total: 100,00

Calculation formula of final grade

The evaluation of the knowledge is performed through a multiple-choice test.
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