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Mechanisms of cardiac injury

Code: PDCCV_12     Acronym: PDCCV_12

Classification Keyword
OFICIAL Medicine

Instance: 2015/2016 - 1S

Active? Yes
Responsible unit: Physiology and Cardiothoracic Surgery Department
Course/CS Responsible: Doctoral Programm in Cardiovascular Sciences

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
PDCCV 7 Ciências Cardiovasculares_13 1 - 3 13,5 81

Teaching Staff - Responsibilities

Teacher Responsibility
Roberto Liberal Fernandes Roncon Albuquerque

Teaching language

Suitable for English-speaking students


Transmit knowledge of the molecular mechanisms of cell injury in cardiac diseases.

Learning outcomes and competences

Students should know and understand:

  1. Inducers of cardiac injury
  2. The cellular mechanisms of aggression
  3. The subcellular pathways activated by aggression
  4. The response of various cell types to aggression
  5. The cell death mechanisms and molecular remodeling and ventricular myocardial

Working method



  1. Ventricular overload. Types of ventricular overload. Myocardial mechanotransduction. Physiological and pathological hypertrophy and its cellular and molecular mechanisms. Reverse remodeling.

  2. Myocardial ischemia. Types of ischemia. Ischemic preconditioning, hibernation and stunning myocardial . Necrosis and apoptosis. Reaction of the ischemic myocardium and remote myocardial ischemia.

  3. Acute and chronic myocardial inflammation. Infectious and noninfectious agents. Reverse remodeling.

  4. Diabetic cardiomyopathy . Adipokines and cardiac remodeling . Cardiomiocitárias changes of the cytoskeleton, the filaments and cell organelles. Changes in the extracellular matrix: fibrosis and AGEs.

Mandatory literature

. Mann, D. L., Zipes, D. P., Libby, P., & Bonow, R. O. ; Braunwald's heart disease: a textbook of cardiovascular medicine. , Elsevier Health Sciences, 2014
Fuster, V., Walsh, R., & Harrington, R. ; Hurst's the Heart, 13th Edition. , McGraw Hill, 2011
Katz, A. M. ; Physiology of the Heart., Lippincott Williams & Wilkins, 2011

Teaching methods and learning activities

Lectures (6h), theoretical and practical sessions (5h) and seminars (2.5 h).

Evaluation Type

Evaluation with final exam

Assessment Components

Designation Weight (%)
Exame 100,00
Total: 100,00

Calculation formula of final grade

The evaluation will be performed by classifying a final multiple choice exam.

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