Instance: 2009/2010 - 1S
Cycles of Study/Courses
Teaching Staff - Responsibilities
Teaching - Hours
To acquire the knowledge of basic mechanisms of the immune response, including the biological response to exogenous or endogenous agents in human pathology.
A – To acquire the knowledge about the cellular, molecular and functional organization of the immune system. B – To be able to collect, analyze and report data from basic immunological techniques; C – To recognize the role of the immune response in the biological response to damage; D – To be able to search and organize information form scientific data bases; E – To acquire initiative and team work capacities.
Teaching methods and learning activities
1. Immunity - concept and biopathological relevance;
2. The Immune system - components and functional organization;
3. B lymphocytes - development and antibody synthesis;
4. T lymphocytes - ontogenesis, antigen recognition immunoregulatory role;
5. Antibodies – structure and fucntion
6. Antigens - immunogenicity and antigen processing;
7. Major histocompatibility complex - structure and participation on the afferent, central and immune responses;
8. Immunological tolerance - mechanisms of central and peripheral immune tolerance;
9. Regulation of the immune response - by the antigen, intrinsic, neuroendocrine and genetic;
10. Effector mechanisms and the amplification of the immune response – complement system, inflammatory cytokines, chemokines. Inflammation and cellular recruitment;
11. Cytokines – regulatory role in B and T lymphocyte response.
Evaluation with final exam
Eligibility for exams
Basic Immunology will have a total of 94.5 learning hours/year (3.5 ECTS), of which 34h (36%) will be teaching classes. These will include 2 classes per week – 1 hour each – of lectures or seminars; group work will represent 1h per week of contact with the teaching team.
Lectures summaries, iconography and bibliographic materials for seminars and group works, will be supplied and available at the Immunology e-learning platform (WebCT Vista) within the University of Porto e-learning project.
Additional bibliography: Immunobiology. Janeway, Travers, Walport, Shlomchik eds. 6th Edition, 2005, Garland Churchill Livingstone. ISBN 0 8153 4101 6; Immunology, Kindt TJ, Goldsby RA, Osborne BA eds. 6th ed, 2006 WH Freeman and Co, ISBN 0 7167 8590 0; Immunology, Male D, Brostoff J, Roth DB, Roitt I eds. 7th Edition; 2006, Mosby Elsevier. ISBN 0 323 03399 7.