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Cellular and Molecular Biology II

Code: MI107     Acronym: BCM2

Classification Keyword
OFICIAL Medicine

Instance: 2009/2010 - 2S

Active? Yes
Web Page: http://medicina.med.up.pt/bcm/
Responsible unit: Laboratory of Cellular and Molecular Biology
Course/CS Responsible: Master Degree in Medicine

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MIMED 320 Mestrado Integrado em Medicina 2007 1 - 8 86 216

Teaching language



A - To provide knowledge on the functional organization of the cytoskeleton, signalization and cellular aggregation mechanisms, cell division and the molecular basis for cell differentiation, desdifferentiation and aging; B – To prepare students for critical assessment of scientific material; C- To prepare students to envisage the usefulness of molecular cell biology research in Clinical Practice.


Cytoskeleton, cellular mobility and contraction; Organelle traffic; specializations of the cell surface; signalization; extracellular matrix; cell adhesion and tissue organization; cell cicle and mitotic division; meiotic division and gametogenesis; oncogenesis; aging.

Mandatory literature

Lodish, e col.; Molecular Cell Biology, Media Connected, W.H. Freeman and Company, 2008
Sadler; Langman’s Medical Embryology, Williams and Wilkins, 2003
Gilbert; Developmental Biology , Sinauer Associates, Inc, 2000
Pollard & Earnshaw; Cell Biology, 2 nd Edition, Saunders, 2008
Alberts, B. e col.; Molecular Biology of the Cell ,5th ed, Garland Publishing ,Inc., 2008. ISBN: ISBN 978-0-8153-4111-6
Cooper, G.M. & Hausman, R.E.; The Cell: A Molecular Approach, ASM Press, 2009

Teaching methods and learning activities

Total period of working load – 88 hours:
Theoretical Learning (T) – 25 hours distributed by 25 sessions of 60 minutes, 2 sessions per week (includes teaching sessions by professors (75%) and sessions of project presentation by students under the item “Complementary Practical Learning” (25%)).
Clinical Seminars (S) – 5 hours distributed by 5 sessions of 60 minutes
Practical Learning – compulsory (PL) – 28 hours in groups of 15 students:
7.5 hours for microscopical observation of the cell; sessions of 1.5 hours
17,5 hours for laboratory protocols; sessions of 2.5 hours
3 hours for problem resolution; sessions of 1.5 hours
Complementary Practical Learning – Optional (OT) – 30 hours; 2 hours/week in groups of 2 to 5 students (according to the type and subject)
Online Learning – Construction of a data base with questions from students and the respective answers prepared by the Faculty
Note: The Complementary Practical Learning consists on the accomplishment of facultative projects to figure online for future students’ consult, and their presentation to students and Faculty at the end of the year. Projects fall into one of the following types:
a) Seminars – Preparation and presentation to colleagues and professors of a subject in the scope of Molecular Cell Biology
b) Monographs – Development of a subject of Molecular Cell Biology to be presented under the written form
c) Webpage – Presentation of a subject of Molecular Cell Biology as a Web page
d) Scientific highlights – Selection and presentation of a particularly relevant, recent scientific article on molecular biology subjects
e) Laboratory Projects: Execution of laboratory tasks throughout the year.
f) Research Projects: Participation in one of the ongoing research projects of the department.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description Type Time (hours) Weight (%) End date
Attendance (estimated) Participação presencial 0,00
Total: - 0,00

Eligibility for exams

Continuous assessment is performed by the teachers in their daily contact with the students, based on their participation in the classes and their performance on mini tests presented in a few practical sessions. Used to monitor the learning process and to correct the classification obtained at the final examination.
Final assessment, consisting on theoretical assessment (compulsory), practical assessment (compulsory) and assessment of the project performed along the year (optional).
Students must reach a minimal classification of 8 (out of 20) in both the theoretical and practical compulsory assessments.
Compulsory assessment (theoretical plus practical) allows a maximal classification of 18 (out of 20). The optional assessment adds 0 to 2 marks (out of 20)
Theoretical assessment (T)
25 multiple choice questions with 5 hypotheses (10 marks), 5 true/false questions (1 mark), 2 problems (4 marks), and 1 essay question (5 marks).
Practical assessment (P)
2 questions for identification of cell components in light or electron microscopy – 5 marks; 4 questions on laboratory items – 10 marks; 1 exercise
– 5 marks
Project assessment (C)
Attributed by the entire teaching staff after presentation – 2 marks.

Calculation formula of final grade

Final assessment
Obtained by the formula {(3T+P)X18/80}+C, for students that attend the complementary practical learning, or the formula (3T+P)X18/80, for the remaining.


Molecular Biology of the Cell - Alberts, B. e al., Garland Publishing, Inc., 4th Edition, New York, 2002; The Cell: A Molecular Approach – Cooper, G.M. & Hausman, R.E., - ASM Press, , 4rd Edition, Washington DC, 2007; Molecular Cell Biology - Lodish, et al., - Media Connected, W.H. Freeman and Company, 5th Edition, New York, 2004; Cell Biology – Update Edition, Thomas, D., Elsevier, 2004; Biologia Celular e Molecular – 3rd Edition, Carlos Azevedo, Lidel, Ed. Technique, Lisbon, 1999; Langman's Medical Embryology – 8th Edition, Sadler, Williams and Wilkins, Baltimore, 1995; Developmental Biology – 6th Edition, Gilbert, Sinauer Associates, Inc. Sunderland, USA, 2000.
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