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Biochemistry II

Code: MI106     Acronym: BIOQ2

Keywords
Classification Keyword
OFICIAL Medicine

Instance: 2009/2010 - 2S

Active? Yes
Web Page: http://medicina.med.up.pt/bioquimica/
Responsible unit: Laboratory of Biochemistry
Course/CS Responsible: Master Degree in Medicine

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MIMED 304 Mestrado Integrado em Medicina 2007 1 - 9 100 243

Teaching - Hours

Theoretical classes: 0,00
Theoretical and practical : 0,00
Practical: 0,00
Laboratory: 0,00
Type Teacher Classes Hour
Theoretical classes Totals 0 0,00
Rita Henriques Pinto de Barros 0,00
Susana Cecília de Brito Gomes Guerreiro 0,00
João Ricardo Diniz Araújo 0,00
João Cláudio Faria Santos Antunes 0,00
Pedro Filipe Fernandes Gonçalves 0,00
Júlio César Leite da Fonseca Rocha 0,00
João Tiago de Sousa Pinto Guimarães 0,00
Laura Virginia Pereira Teixeira Ribeiro 0,00
Maria João dos Reis Conceição Martins de Almeida Ribeiro 0,00
Rui Manuel Fontes Gonçalves 0,00
Maria de Fátima Moreira Martel 0,00
Diana Marina Silva Teixeira 0,00
Raquel Ângela Silva Soares Lino 0,00
Manuel Nuno de Magalhães Pinheiro Alçada 0,00
Theoretical and practical Totals 0 0,00
Júlio César Leite da Fonseca Rocha 0,00
Maria de Fátima Moreira Martel 0,00
Raquel Ângela Silva Soares Lino 0,00
Tiago Manuel Bernardino Gomes 0,00
Maria Lima Carneiro Cavaleiro 0,00
Tiago José Andrade Gregório 0,00
Elisa Oliveira Braga Keating 0,00
Maria João dos Reis Conceição Martins de Almeida Ribeiro 0,00
Maria da Conceição Costa Pinho Calhau 0,00
Manuel Nuno de Magalhães Pinheiro Alçada 0,00
Laboratory Totals 0 0,00
João Tiago de Sousa Pinto Guimarães 0,00
Rui Manuel Fontes Gonçalves 0,00
Laura Virginia Pereira Teixeira Ribeiro 0,00
Susana Cecília de Brito Gomes Guerreiro 0,00
João Ricardo Diniz Araújo 0,00
Maria Rita Baldaque Sousa Soares da Silva Negrão 0,00
Pedro Filipe Fernandes Gonçalves 0,00

Teaching language

Portuguese

Objectives

To contribute, in conjunction with other knowledge in the area of human biology and medicine, to the comprehension of the human biology. To contribute, in conjunction with the chair of Biochemistry I, to the acquisition of the specific language of biochemistry and of the knowledge of the methods of study in this scientific area. Knowledge of the chemical composition of living organisms, the chemical transformations ocurring inside them and the factors that affect those transformations.

Program

Study of lipidic and aminoacid metabolism and their regulation. Namely: synthesis and oxidation of fatty acids, metabolism of ketone bodies, synthesis of phospholipids and glycolipids, structure and metabolism of plasma lipoproteins, metabolism of triacylglycerols, oxidation of ethanol, metabolism of cholesterol and bile acids, general metabolism of the proteins, synthesis, catabolism and nitrogen metabolism of aminoacids, conversion of aminoacids into derivatives with specific biological roles, metabolism of the heme, purines and pyrimidines, role of vitamins B6, B12 and folates. Themes that will help the students to integrate and correlate aspects of carbohydrate, lipidic and protein metabolism and factors that affect those metabolisms: intercellular signalling, signal transduction, fed-fast cycle, interdependence of different organs and tissues, biochemisty of the extracellular matrix, physical exercise, regulation and factors that affect acid-base, energetic and nitrogen balance in human beings, and human nutrition. Themes selected with the purpose of showing the importance of the investigation and knowledge in the area of biochemistry for the comprehension and treatment of common human pathologies: disorders of lipoprotein metabolism, alcohol and alcoholic drinks, diabetes, obesity, caquexia, stress and genetic diseases of aminoacid metabolism. The program referred above will be developed in lectures, seminars and small group classes. In a consecutive series of practical sessions an investigation project about alkaline phosphatase will be developed. Two practical sessions will be dedicated to urine analysis and to the study of a bulletin of clinical analysis.

Teaching methods and learning activities

Weekly, 2 lectures of 1 hour each, 1 seminar of 1 hour, 1 practical session of 2h30 and a small group class of 2h30 in a total of 100 hours per student. An exercise of "calibrated peer review" is also proposed. The time invested by the student in Biochemistry I is estimated to be about 300 hours.

keywords

Physical sciences > Chemistry > Analytical chemestry > Clinical chemistry
Physical sciences > Chemistry > Biochemistry > Metabolism
Physical sciences > Chemistry > Biochemistry > Enzimology
Physical sciences > Chemistry > Biochemistry

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description Type Time (hours) Weight (%) End date
Attendance (estimated) Participação presencial 0,00
Total: - 0,00

Eligibility for exams

Assessment will be made through a written exam (E), with a series of multiple-choice questions (group I) and 3 groups of questions, group II with 2 open questions/ problems/ essay questions and groups III and IV each one with 3 open questions/ problems/ essay questions (the student choose to answer only one question in each group). Students with less then 27 correct answers in group I will fail. The result obtained in the exam (E) will be adjusted according to the mark obtained in the continuous assessment in the small group classes (AG), in the practical sessions (AP) and in the exercise of "calibrated peer review" (CPR). In the case of the students that have obtained more then a specified mark in group I the Final Mark (FM) will be obtained applying the following equation:
FM = E x 0,74 + AG x 0,13 + AP x 0,10 + CPR x 0,03
However, FM cannot be higher then E+2 and cannot be less then E.

To be evaluated in the exam the student have to be present in, at least, 2/3 of the sum of the small group and practical lessons that have been teached.

Calculation formula of final grade

FM = E x 0,74 + AG x 0,13 + AP x 0,10 + CPR x 0,03

Observations

Bibliography:
Biochemistry Berg J M, Tymoczko J L, Stryer L. 6th Edition, International Edition. W H Freeman and Company. New York, 2006; Harper's Illustrated Biochemistry Murray R K, Granner D K, Rodwell V W. 27th Edition, Lange Medical Books/McGraw-Hill, Boston, 2006; Medical Biochemistry Baynes J W, Dominiczak M H, 2nd Edition, Elsevier Mosby, New York, 2005; Práticas de Bioquímica para as Ciências da Saúde Hipólito-Reis C, Alçada M N, Azevedo I. Lidel, 2002; Biochemical, Physiological, Molecular Aspects of Human Nutrition Stipanuk M H. Elsevier Saunders. St Louis, 2006.
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