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Cellular and Molecular Biology I

Code: MI103     Acronym: BCM1

Classification Keyword
OFICIAL Medicine

Instance: 2009/2010 - 1S

Active? Yes
Web Page: http://medicina.med.up.pt/bcm/
Responsible unit: Laboratory of Cellular and Molecular Biology
Course/CS Responsible: Master Degree in Medicine

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MIMED 301 Mestrado Integrado em Medicina 2007 1 - 7 58 189

Teaching language



A - To provide knowledge of the molecular and structural constitution, organization and functioning of the components of the living cells, and on the mechanisms of origin, growth and development of the cell; B – To teach the students how to use and apply techniques of molecular biology and light and electron microscopy


Concept and objectives of Cellular and Molecular Biology; Techniques used in Cellular and Molecular Biology; Structural and chemical organization of the cell; DNA replication and repair; Transcription and translation; Regulation of gene expression; Biologic membranes; Protein intracellular traffic.

Mandatory literature

Lodish, e col.; Molecular Cell Biology, Media Connected, W.H. Freeman and Company, 2008
Pollard & Earnshaw; Cell Biology, 2 nd Edition, Saunders, 2008
Alberts, Johnson, Walter, Lewis, Raff e Roberts ; Molelular Biology of the Cell 5 th ed., Garland Science textbooks , 2008. ISBN: 978-0-8153-4111-6
Cooper, G.M. & Hausman, R.E.; The Cell: A Molecular Approach, , ASM Press, 2009

Teaching methods and learning activities

Total period of working load – 58 hours:
Theoretical Learning (T) – 25 hours distributed by 25 sessions of 60 minutes, 2 sessions per week
Clinical Seminars (S) - 5 hours distributed by 5 sessions of 60 minutes
Practical Learning (PL) – 28 hours, in groups of 15 students:
7.5 hours of microscopical observation of the cell; sessions of 1.5 hours
17,5 hours of laboratory protocols; sessions of 2.5 hours
3 hours of problem resolution; sessions of 1.5 hours
Online Learning – Construction of a data base with questions from students and the respective answers prepared by the Faculty.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description Type Time (hours) Weight (%) End date
Attendance (estimated) Participação presencial 0,00
Total: - 0,00

Eligibility for exams

Continuous assessment is performed by the teachers in their daily contact with the students, based on their participation in the classes and their performance on mini tests presented in a few practical sessions. Used to monitor the learning process and to correct the classification obtained at the final examination.

Calculation formula of final grade

Final assessment, consisting on theoretical assessment and practical assessment.
Students must reach a minimal classification of 8 (out of 20) in both the theoretical and practical assessments.
Theoretical assessment (T)
25 multiple choice questions with 5 hypotheses (10 marks); 5 true/false questions (1 mark); 2 problems (4 marks), and 1 essay question (5 marks).
Practical assessment (P)
2 questions for identification of cell components in light or electron microscopy – 5 marks; 4 questions on laboratory items – 10 marks; 1 exercise – 5 marks.
Final assessment
Obtained by the formula (3T+P)/4.


Molecular Biology of the Cell - Alberts, B. e al., Garland Publishing, Inc., 4th Edition, New York, 2002; The Cell: A Molecular Approach – Cooper, G.M. & Hausman, R.E., - ASM Press, , 4rd Edition, Washington DC, 2007; Molecular Cell Biology - Lodish, et al., - Media Connected, W.H. Freeman and Company, 5th Edition, New York, 2004; Cell Biology – Update Edition, Thomas, D., Elsevier, 2004; Biologia Celular e Molecular – 3rd Edition, Carlos Azevedo, Lidel, Ed. Technique, Lisbon, 1999; Langman's Medical Embryology – 8th Edition, Sadler, Williams and Wilkins, Baltimore, 1995; Developmental Biology – 6th Edition, Gilbert, Sinauer Associates, Inc. Sunderland, USA, 2000.
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