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Biochemistry I

Code: MI102     Acronym: BIOQ1

Keywords
Classification Keyword
OFICIAL Medicine

Instance: 2009/2010 - 1S

Active? Yes
Web Page: http://medicina.med.up.pt/bioquimica/
Responsible unit: Laboratory of Biochemistry
Course/CS Responsible: Master Degree in Medicine

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MIMED 292 Mestrado Integrado em Medicina 2007 1 - 8 100 216

Teaching language

Portuguese

Objectives

To contribute, in conjunction with other human biology and medicine disciplines, to the knowledge of human biology. To contribute, in conjunction with the discipline of Biochemistry II, to the acquisition of the specific language of biochemistry and to the knowledge of the methods of study in this scientific area. Knowledge of the chemical composition of living organisms, the chemical transformations occurring inside them and the factors that affect those transformations.

Program

Structural aspects, denomination and biological role of the chemical components of living organisms with special attention to those that take part in the constitution of the human being or interact with it (as the nutrients), namely: carbohydrates, lipids, proteins, glycoproteins, glycated proteins, aminoacids, vitamins and inorganic compounds, including water and phase systems. Acid-base and redox reactions with special attention to the ones that involve organic compounds and are relevant to living organisms. Aspects of thermodynamics and kinetics that are relevant to understand the direction and the velocity of chemical transformations and the transport of substances between different compartments. Role, specificity and nomenclature of enzymes and membrane transporters. Basic concepts in enzyme kinetics. General mechanisms of enzyme activity regulation. Selected themes with the objective of showing the importance of the investigation and knowledge in biochemistry for the understanding and the treatment of human diseases: investigation in Medicine, lactose intolerance, glycemic index, enzymes and clinical chemistry, radiations, radicals and oxidative stress defense mechanisms, anti-oxidants, genetic diseases of carbohydrate metabolism and respiratory stress of the newborn. Digestion and absorption of carbohydrates, lipids and proteins. Study of carbohydrate metabolism and its regulation, namely: glycolysis, piruvate oxidation, pentose-phosphate pathway, NADPH consumption, glycogenesis, glycogenolysis, glyconeogenesis and metabolism of galactose, fructose, glucoronate and amino sugars. Study of the pathways that are common in the oxidation of all nutrients (Krebs cycle and oxidative phosphorylation) and its relationship with the formation and hydrolysis of ATP. Importance of the chemical components of the human beings and the transformations they undergo to the health and to the development of pathologic processes using examples. The program referred above will be developed in lectures, seminars, small group classes and in a “lesson on-line” (LOL). In practical laboratory sessions, two research projects will be developed; in these projects the students will study the effect of some foods on glycaemia and in parameters that evaluate the oxidative state.

Mandatory literature

Baynes JW, Dominiczak MH; Medical Biochemistry, Elsevier Mosby, 2005
Berg J.M., Tymoczko J.L. and Stryer L.; Biochemistry, International Edition. W.H. Freeman and Company, 2002
Hipólito-Reis C., Alçada MN., Azevedo I.; Práticas de Bioquímica para as Ciências da Saúde, Lidel, 2002
Murray R.K., Granner D.K., Mayes P.A. and Rodwell V.W.; Harper's Biochemistry, Prentice-Hall International Inc, 2006
Nelson D.L., Cox M.M.; Lehningher Principles of Biochemistry, W.H. Freeman and Company, 2005
Stipanuk M.H.; Biochemical, Physiological & Molecular Aspects of Human Nutrition, Elsevier Science, 2006

Complementary Bibliography

Quintas A., Freire, A.P., Halpern M.J.; Bioquímica – Organização Molecular da Vida, Lidel-Edições Técnicas, Lda, 2008

Teaching methods and learning activities

Weekly, 2 lectures of 1 hour each, 1 seminar of 1 hour, 1 practical session of 2h30 and a small group class of 2h30 in a total of 90 hours per student. A “lesson on-line” is also proposed. The time invested by the student in Biochemistry I is estimated to be about 300 hours.

keywords

Physical sciences > Chemistry > Biochemistry > Metabolism
Physical sciences > Chemistry > Biochemistry > Enzimology
Physical sciences > Chemistry > Analytical chemestry > Clinical chemistry
Physical sciences > Chemistry > Biochemistry
Physical sciences > Chemistry > Organiz chemistry

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description Type Time (hours) Weight (%) End date
Attendance (estimated) Participação presencial 90,00
Online lesson (LOL) Trabalho escrito 10,00
Final exam Exame 2,00
Total: - 0,00

Eligibility for exams

Assessment will be made through a written exam (E), with a series of multiple-choice questions (group I) and 3 groups of questions (groups I, II and III), Group II with 2 proposals and Groups III e IV with 3 proposals (the student choose to answer only one question in each group). The result obtained in the exam (E) will be adjusted according to the mark obtained in the continuous evaluation obtained in the small group classes (AG), in the practical sessions (AP), in the "calibrated peer review" exercise (CPR) and in the “lesson on-line” (LOL). In the case of the students that have obtained more then a specified mark in group I the Final Mark (FM) will be obtained by applying the following equation:
FM = E x 0,74 + AG x 0,13 + AP x 0,10 + LOL x 0,03
However, FM cannot be higher then E+2 and cannot be less then E.

To be evaluated in the exam the student have to be present in, at least, 2/3 of the sum of the small group and practical lessons that have been teached.

Calculation formula of final grade

FM = E x 0,74 + AG x 0,13 + AP x 0,10 + LOL x 0,03
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