Prediagnosis lifestyle exposures and survival of gastric cancer patients: a cohort study from Portugal

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Ferronha, I (Author) Other; Castro, C (Author) Other; Carreira, H (Author) Other; Bento, MJ (Author) Other; Carvalho, I (Author) Other; peleteiro, b (Author) FMUP; Lunet N (Author) FMUP

Journal

Title: British Journal of Cancer

Vol. 107

Pages: 537-543

ISSN: 0007-0920

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-002-7WV

DOI: 10.1038/bjc.2012.258

Abstract (EN): BACKGROUND: Dietary habits and smoking are recognised as important gastric cancer determinants. However, their impact on prognosis remains poorly understood. We aimed to quantify the association between lifestyles and survival of gastric cancer patients. METHODS: In 2001-2006, 568 patients were recruited in the two major public hospitals in the north of Portugal. Participants were inquired about smoking and dietary habits regarding the year preceding the diagnosis. The vital status of all participants, up to 2011 (maximum follow-up: 10 years), was assessed through the North Region Cancer Registry. Cox proportional hazards regression models were used to estimate adjusted (at least for age, sex and education) hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: No significant differences in gastric cancer survival were observed according to smoking status (current vs never smokers, HR = 1.00, 95% CI: 0.72-1.38) or alcohol intake (current vs never consumers, HR = 0.87, 95% CI: 0.61-1.25). Only a dietary pattern (high consumptions of most food groups and low vegetable soup intake) was significantly associated with a better prognosis among patients with the extent of disease classified as regional spread (HR = 0.45, 95% CI: 0.22-0.93). CONCLUSION: This study shows that prediagnosis lifestyles have a small impact in the survival of gastric cancer patients. British Journal of Cancer (2012) 107, 537-543. doi: 10.1038/bjc.2012.258 www.bjcancer.com Published online 14 June 2012 (C) 2012 Cancer Research UK

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7