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Molecular Structure of the Cell

Code: MI120     Acronym: EMC

Keywords
Classification Keyword
OFICIAL Medicine

Instance: 2021/2022 - 1S (of 13-09-2021 to 13-02-2022) Ícone do Moodle

Active? Yes
Responsible unit: Departamento de Biomedicina
Course/CS Responsible: Master Degree in Medicine

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
MIMED 290 Plano Oficial 2021 1 - 7 66 189

Teaching Staff - Responsibilities

Teacher Responsibility
João Tiago de Sousa Pinto Guimarães
Maria Isabel Torres Martins

Teaching - Hours

Theoretical classes: 2,00
Theoretical and practical : 1,14
Laboratory Practice: 1,57
Type Teacher Classes Hour
Theoretical classes Totals 1 2,00
Raquel Ângela Silva Soares Lino 0,072
Maria de Fátima Moreira Martel 0,072
Rui Manuel Fontes Gonçalves 0,429
Maria Isabel Torres Martins 0,143
Joaquim Jorge Gonçalves Ferreira 0,072
Manuel Nuno de Magalhães Pinheiro Alçada 0,321
Maria João dos Reis Conceição Martins de Almeida Ribeiro 0,143
Maria Rita Baldaque Sousa Soares da Silva Negrão 0,072
Delfim Diogo Ferreira Duarte 0,071
Delminda Rosa Gamelas Neves Lopes de Magalhães 0,285
Filipe Almeida Monteiro 0,142
João Tiago de Sousa Pinto Guimarães 0,178
Theoretical and practical Totals 10 11,42
Maria Rita Baldaque Sousa Soares da Silva Negrão 0,972
Elisa Oliveira Braga Keating 0,972
Carlos Manuel Gomes Reguenga 0,178
Alexandra Maria Monteiro Gouveia 0,71
Filipe Almeida Monteiro 0,535
Maria Isabel Torres Martins 0,535
Maria de Fátima Moreira Martel 0,971
Manuel Nuno de Magalhães Pinheiro Alçada 0,972
Raquel Ângela Silva Soares Lino 0,971
Rui Manuel Fontes Gonçalves 0,971
João Tiago de Sousa Pinto Guimarães 0,971
Helder José Martins Maiato 0,357
Maria João dos Reis Conceição Martins de Almeida Ribeiro 0,971
Clara Maria Pires Costa Bastos Monteiro 0,893
Delminda Rosa Gamelas Neves Lopes de Magalhães 0,357
Laboratory Practice Totals 20 31,42
Maria de Fátima Moreira Martel 2,137
João Tiago de Sousa Pinto Guimarães 2,137
Manuel Nuno de Magalhães Pinheiro Alçada 2,137
Delminda Rosa Gamelas Neves Lopes de Magalhães 1,11
Filipe Almeida Monteiro 1,53
Joaquim Jorge Gonçalves Ferreira 1,53
Maria João dos Reis Conceição Martins de Almeida Ribeiro 3,206
Maria Rita Baldaque Sousa Soares da Silva Negrão 2,137
Elisa Oliveira Braga Keating 2,137
Alexandra Maria Monteiro Gouveia 0,65
Maria Isabel Torres Martins 1,50
Rui Manuel Fontes Gonçalves 4,274
Clara Maria Pires Costa Bastos Monteiro 2,00
Helder José Martins Maiato 0,357
Raquel Ângela Silva Soares Lino 2,137
Carlos Manuel Gomes Reguenga 1,32
Delfim Diogo Ferreira Duarte 1,069

Teaching language

Portuguese

Objectives

1. we will always try to keep in mind the medical nature of the course, namely by highlighting the clinical relevance of the subjects;

2. we intend to interconnect the areas as much as possible, either by including subjects that were classically attributed to Biochemistry and Cellular Biology, or by involving teachers from two of the units of FMUP's Biomedicine Department (Biochemistry and Experimental Biology);

3. we will value the learning along the semester, keeping the weight of the continuous assessment and performing two written tests of knowledge assessment;

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Learning outcomes and competences

Competences: Understand the specific vocabulary of Biochemistry and Cell Biology. Have the ability to use the knowledge of Biochemistry and Cell Biology in critical analysis of information and practice of other medical disciplines. Have the ability to collect information on a biochemical subject and present it in an intelligible and contextualised manner. Have basic laboratory skills in a Biochemistry or Cell Biology laboratory. Understand the role of scientific research for the analysis and possible resolution of medical problems.

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Working method

Presencial

Program

1- Lectures (distance and asynchronous learning): will be taught structural topics of Biochemistry and Cell Biology with emphasis on Medicine. As already mentioned, we had present the introductory nature of this UC in the way the subjects were chosen and aligned. Thus, it will be relevant the denomination and the biological role of the chemical constituents of living beings with special attention to those that are part of the human being constitution or that interact with it (such as nutrients), namely: glycids, lipids, proteins, glycoproteins, glycated proteins, amino acids, inorganic compounds and water. The main concepts and methodologies of cell study will be addressed, particularly the structure of membranes and their role in transport and the structure of the extracellular matrix and filaments and microtubular system. The function, specificity and nomenclature of enzymes and the basics of enzyme kinetics, the general factors and mechanisms modifying enzyme activity, as well as acid-base reactions, the relationship of water to lipids and the meaning of phase systems will also be covered. The importance of uncertainty and error in Biochemistry and Medicine are also subjects of this course.

2- The seminars, which are presential, are classes in which we discuss and present subjects in a more integrative way. We will address the vitamins and some hormones, as well as deepen the knowledge of this central structure that is the cell.

3- Group lessons, also face-to-face, will be specially focused on how our body obtains and uses some of the structural forms essential to numerous functions, as well as corresponding clinical conditions:

Digestion and absorption of glycides. Structure of the most abundant glycogen in the diet. Digestion of starch, glycogen and disaccharides. Absorption and transport of glycogen in enterocyte membranes.
Digestion and absorption of proteins and nucleotides. Structure and biological role of amino acids. The digestive zymogens and their activation. The exo and endopeptidases. Digestion and absorption of lipids. Relationship between the structure of lipids, their solubility and their digestion. Role of bile salts in the digestion of lipids. The enzymes involved in the digestion of lipids.

4- In practical laboratory classes, which will be presential, students will have the opportunity to contact with some of the basic laboratory techniques in these areas and whose knowledge will be useful in other UCs. Within these classes will be developed a small project which will study the effect of nutrient intake on blood glucose, trying to take into account its meaning and relationship with diabetes.

Translated with www.DeepL.com/Translator (free version)

Mandatory literature

Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P; Molecular Biology of the Cell, 6th Ed. Garland Publishing, Inc. New York, 2015. ISBN: 978-0815345244
Rodwell V.W., Kennelly P.J., Bender D.A., Botham K.M. and Weil P.A; Harpers Illustrated Biochemistry, 30th Edition. McGraw-Hill Medical. London, 2015. ISBN: 9781259252860
John Baynes, Marek Dominiczak; Medical Biochemistry, 5th Ed. Elsevier, 2018. ISBN: 9780702073007
Lodish H., Berk A., Kaiser C.A., Krieger M., Bretscher A, Ploegh H., Amon A and Martin K.C; Molecular Cell Biology, 8th Ed. W.H. Freeman and company, New York, 2015. ISBN: 9781464183393

Complementary Bibliography

Frayn K.N; Regulação Metabólica, 3rd Ed. U.Porto Editorial. Porto, 2012. ISBN: 978-989-8265-93-7
Hipólito-Reis C., Alçada MN., Azevedo I; Práticas de Bioquímica para as Ciências da Saúde, Lidel, Lisboa, 2002. ISBN: 978-972-757-245-8
Nelson D.L., Cox M.M; Lehningher Principles of Biochemistry, 6th Ed W.H. Freeman and Company, 2013. ISBN: 978-1429234146

Teaching methods and learning activities

Lectures, seminars, group classes and practical laboratory classes.

keywords

Physical sciences > Chemistry > Biochemistry > Enzimology
Physical sciences > Chemistry > Biochemistry
Natural sciences > Biological sciences > Biology > Cell biology

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation Weight (%)
Participação presencial 10,00
Teste 90,00
Total: 100,00

Amount of time allocated to each course unit

Designation Time (hours)
Estudo autónomo 123,00
Frequência das aulas 66,00
Total: 189,00

Eligibility for exams

The participation in intermediate evaluations or in the exam, is conditioned to the presence in 75% of the total of the practical and group classes (that is, in this CU, maximum of 4 absences).

Calculation formula of final grade

NF = [(E1 + E2 + CE) x 0,1], for intermidiate assessment

NF = [(EX + CE) x 0,1], for the exam

E1 and E2- intermediate assessments
CE- continous assessment

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