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Invasive hemodynamic evaluation

Code: PDCCV_15     Acronym: PDCCV_15

Classification Keyword
OFICIAL Medicine

Instance: 2015/2016 - 2S

Active? Yes
Responsible unit: Physiology and Cardiothoracic Surgery Department
Course/CS Responsible: Doctoral Programm in Cardiovascular Sciences

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
PDCCV 3 Ciências Cardiovasculares_13 1 - 3 13,5 81

Teaching Staff - Responsibilities

Teacher Responsibility
André Pedro Leite Martins Lourenço

Teaching language

Suitable for English-speaking students


Approach the major methodologies for evaluation of pressures, flows and volumes on the cardiovascular system, including simple evaluation of ventricular pressure and joint assessment of pressure and volume, including the advantages and disadvantages of each of them.

Learning outcomes and competences

Students should have a good knowledge of basic concepts: (i) haemodynamics, (ii) evaluation of pressure and flow, and (iii) catheters and transducers of pressure and flow. Know (i) methodologies for invasive and non-invasive assessment, (ii) experimental preparations with and without anesthesia, (iii) experimental preparations with open and closed chest, and (iv) influence of ventricular interaction and neuroendocrine systems. Know the main methodologies for assessment of ventricular function in vivo, as well as the indices of systolic and diastolic function. Understand the representation of the cardiac cycle as pressure-volume loop and understand the roles played by pre-load, after-load, contractility and compliance. Understand the characterization of ventricular systolic and diastolic properties from end-systolic and end-diastolic pressure-volume relationships. Application of concepts to clinical practice and scientific literature.

Working method



Basics of haemodynamics. Pressure and flow assessment: techniques and methodologies. Catheters and transducers for pressure and flow measurement: techniques and methodologies. Methodologies for evaluating ventricular volumes in real time. Systolic and diastolic function indices obtained by analysis of pressure. Indexes of relaxation: methodologies for calculation of the isovolumetric relaxation time constant (tau). Dependence of load. Joint analysis of variations of pressure and ventricular volume throughout the cardiac cycle. Transient load manipulation to obtain robust and independent indices of contractility and filling capacity. Changes in cardiovascular pathology. Invasive and non-invasive evaluation. Experimental preparations with and without anaesthesia. Anaesthesia for invasive assessment methods and its haemodynamic effects. Experimental preparations with open and closed chest. Analysis of clinical cases and literature.

Mandatory literature

Pacher, P., Nagayama, T., Mukhopadhyay, P., Batkai, S., & Kass, D. A. ; Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats. , Nat Protoc, 3(9), 1422-1434. doi: 10.1038/nprot.2008.138, 2008
Kottam, A. T., Porterfield, J., Raghavan, K., Fernandez, D., Feldman, M. D., Valvano, J. W., & Pearce, J. A. ; Real time pressure-volume loops in mice using complex admittance: measurement and implications. , Conf Proc IEEE En, 2006
Burkhoff, D., Mirsky, I., & Suga, H. ; Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers. , Am J Physiol Heart Circ Physiol, 289(2), H501-512. doi: 10.1152/ajpheart.00138.2005, 2005
Lourenço, A., Falcão-Pires, I., & Leite-Moreira, A. ; In Vivo Experimental Assessment of Cardiac Function. In D. V. Cokkinos (Ed.), Introduction to Translational Cardiovascular Research, Springer International Publishing; pp. 389-411, 2014

Teaching methods and learning activities

Theoretical and pratical sessions.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation Weight (%)
Exame 50,00
Trabalho laboratorial 50,00
Total: 100,00

Calculation formula of final grade

Theoretical evaluation of content (examen 50%) and evaluation of participation in practical sessions (lab work 50%).
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