In silico Based Structural Analysis of Some Piperidine Analogs as Farnesyltransferase Inhibitors

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Narayana Subbiah Hari Narayana Moorthy (Author) Other; Sergio F Sousa (Author) FCUP; Maria J Ramos (Author) FCUP; Pedro A Fernandes (Author) FCUP

Journal

Title: Medicinal Chemistry

Vol. 8

Pages: 853-864

ISSN: 1573-4064

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-5TW

DOI: 10.2174/157340612802084171

Abstract (EN): In silico based QSAR and pharmacophore analyses of a series of piperidine derivatives were performed in order to investigate the structural features of the derivatives responsible for FTase inhibitory activity. The results derived from the QSAR analysis show that the FTase inhibitory activity mediated by the vdW surface area features such as partial charge (PEOE_VSA and Q_VSA) and v_surf (hydrophobic integy moment) of the molecules. The positive contribution of the partial charge descriptors such as Q_VSA_FPNEG and PEOE_VSA-4 reveal that the fractional negative charge on the vdW surface of the molecules and the aqueous solubility (LogS) of the molecules are important for the FTase inhibitory activity. While the hydrophobic integy moment reveals that a clear separation between the hydrophobic and the hydrophilic region in the molecules is important with electrostatic groups (fractional negative charge) for better activity. The pharmacophore analyses of the piperidine derivatives also show that the aromatic, acceptor and donor groups on the molecule favorable for the FTase inhibitory activity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12