Immunology

Code:

MIMD020103

Acronym:

IMUNO

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2022/2023 - 1S

Active?	Yes
Responsible unit:	Mestrado Integrado
Course/CS Responsible:	Integrated Master in Dental Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMD	75	Official Plan from the academic year 2020/2021	2	-	4	54	108
		NÃO INSCREVER - Plano exclusivo para uso administrativo	2	-	4	54	108

Teaching language

Portuguese

Objectives

Acquisition of knowledge in basic Immunology and its application in physiological and pathological situations. Acquisition of skills for critical analysis of basic and advanced bibliographic information in the subject area of immunology. Acquisition of skills in the use of immunological methods and techniques. Acquisition of self-learning habits and methods.

Learning outcomes and competences

Working method

Presencial

Program

1. Introduction to the immune system.
1.1. General introduction to the immune system.
1.2. Overview of hematopoiesis.

2. Innate Immunity
2.1. Effector mechanisms (phagocytic cells, complement, inflammation).
2.2. Molecular patterns associated with pathogens (PAMPs) and their recognition (PRRs).

3. Acquired immunity. Structural, molecular and cellular components of the immune system and antigen recognition.
3.1. Central and peripheral lymphoid organs and hematopoietic development.
3.2. MHC. Antigenic coding and presentation.
3.3. Immunoglobulins. B cell receptor (BCR).
3.4. Antigen-antibody reactions.
3.5. V(D)J recombination and generation of diversity in immunoglobulins and the T cell receptor.
3.6. T Cell Receptor (TCR). Structure and function.

4. Ontogenesis and dynamics of lymphocyte populations.
4.1. B cell ontogenesis and activation
4.2. T and NK cell maturation.
4.3. T cell activation and mechanisms of T-B cell cooperation.

5. Mechanisms for effecting the immune response.
5.1. Cytokines. T cell differentiation and function.
5.2. Immune response to infection.
5.3. Immunity on body surfaces, emphasizing the particular case of the oral mucosa.
5.4. Vaccines.

6. The immune system under physiological and pathological conditions.
6.1. Hypersensitivity reactions.
6.2. Tolerance and autoimmunity.
6.3. Transplants and implants.
6.4. Primary and secondary immunodeficiencies.
6.5. Immunological response against tumors and implications for immunotherapeutic approaches.

7. Immunological methods and clinical cases
7.1. Morphology of lymphoid organs.
7.2. Production of monoclonal antibodies
7.3. B cell response to a mitogen. Serum immunoglobulin assay by “Sandwich-ELISA”.
7.4. Flow cytometry.
7.5. immunopathology
7.6. Discussion of clinical cases.

Mandatory literature

Abul K. Abbas, Andrew H. H. Lichtman, Shiv Pillai; Cellular and Molecular Immunology, Elsevier, 2017. ISBN: 9780323479783

Complementary Bibliography

K. Murphy & C. Weaver; Janeway's Immunobiology, Garland Science, 2016. ISBN: 978-0-8153-4551-0

Teaching methods and learning activities

Theoretical classes. Laboratory practical classes. Discussion of clinical cases.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Estudo autónomo	54,00
Frequência das aulas	54,00
Total:	108,00

Eligibility for exams

According to the General Regulations for Student Assessment of the University of Porto, a student is considered to comply with a curricular unit if, having been regularly enrolled, he does not exceed the limit number of absences corresponding to 25% of the foreseen classes, as regulated existing in the organic unit.

Calculation formula of final grade

Distributed assessment with final exam