Biochemistry I
Keywords |
Classification |
Keyword |
OFICIAL |
Physical Sciences |
Instance: 2020/2021 - 1S
Cycles of Study/Courses
Teaching language
Portuguese
Objectives
1. To rationalize living systems in terms of basic Chemistry principles. To present Biological Chemistry as a mere subset of Chemistry.
2. To correlate knowledge from Organic and Inorganic Chemistry with Biological Chemistry.
3. To acquire specific knowledge about biological molecules and the cellular chemical organization.
4. Aspects of the specific Biological Chemistry of teeth and saliva.
5. To acquire some practical skills on chemical, biochemical and spectroscopic laboratorial methods.
Learning outcomes and competences
1. To rationalize living systems in terms of basic Chemistry principles. To present Biological Chemistry as a mere subset of Chemistry.
2. To correlate knowledge from Organic and Inorganic Chemistry with Biological Chemistry.
3. To acquire specific knowledge about biological molecules and the cellular chemical organization.
4. Aspects of the specific Biological Chemistry of teeth and saliva.
5. To acquire some practical skills on chemical, biochemical and spectroscopic laboratorial methods.
Working method
Presencial
Program
THEORETICAL AND THEORETICAL-PRACTICAL CLASSES
1. Elements of General Chemistry: acid/base equilibrium, pH buffers; solubility equilibrium.
2. Organic Chemistry elements.
3. Structure and function of biological molecules: carbohidrates, lipids, proteins, nucleic acids; kinetic and thermodynamic stability; intermolecular bonding and molecular recognition.
4. Enzymes: catalysis, selectivity, kinetics (Michaelis-Menten) and regulation.
5. Aspects of oral biological chemistry: saliva composition (buffer systems) and teeth compostition (minerals and solubility).
6. UV/VIS spectrophotometry; Interpretation and treatment of experimental data.
LABORATORIAL CLASSES
1. Basic chemistry laboratory techniques.
2. Preparation of a pH buffer.
3. Identification reactions for sugars.
4. Quantification of total cholesterol in human blood serum.
5. Electrophoresis of proteins in human blood serum.
6. Spectrophotometry of natural DNA.
Mandatory literature
P. W. Atkins and Julio de Paula; Physical Chemistry for the Life Sciences, W H Freeman & Co, 2nd Edition., 2011
T.W. Graham Solomons and Craig B. Fryhle; Organic Chemistry, John Wiley & Son, Inc, 10th Edition., 2011
K. Peter, C, Vollhardt, Neil E. Schore; Organic Chemistry Structure and Function, W. H. Freeman and Company, New York, 4th Edition., 2003
José Augusto Pereira; Apontamentos de Química Biológica, ICBAS, 2014
D.M. Vasudevan, S. Sreekumari, Kannan Vaidyanathan; Textbook of Biochemistry For Dental Students, Jaypee Brothers Medical Publishers LTD, New Delhi, Panama City, London, 2nd Edition, 2011. ISBN: 978-93-5025-488-2
Teaching methods and learning activities
Theoretical classes consist of oral and PowerPoint presentation of the different programmatic topics, with continuous interaction with the students.
Theoretical-practical classes for the elaboration of exercises related to the syllabus of the course.
Practical classes involving laboratory experiments.
Evaluation Type
Distributed evaluation with final exam
Assessment Components
Designation |
Weight (%) |
Exame |
100,00 |
Total: |
100,00 |
Amount of time allocated to each course unit
Designation |
Time (hours) |
Estudo autónomo |
54,00 |
Frequência das aulas |
81,00 |
Total: |
135,00 |
Eligibility for exams
According to the General Regulation of the University of Porto Learners Assessment is considered a student fulfills the attendance to a course if, having been regularly enrolled, does not exceed the number limit faults corresponding to 25% of the foreseen classes, as regulated in the existing organizational unit.
Calculation formula of final grade
Classification in the distributed or final written exams.