Molecular and Cell Biology II

Code:

MD1203

Acronym:

BCM II

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2016/2017 - 2S

Active?	Yes
Responsible unit:	Mestrado Integrado
Course/CS Responsible:	Integrated Master in Dental Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMD	89	PLANO OFICIAL 2007/2008 BOLONHA	1	-	6	90	162

Teaching language

Portuguese

Objectives

 - Acquisition of knowledge related to the composition, structure, function and metabolism of nucleic acids
- Acquisition of theoretical skills into the molecular mechanisms related to the maintenance, expression and transmission of genetic information
- Recognition of the underlying molecular complexity to all cells
- Understanding the mechanisms related to the characteristics of different cell types
- Knowledge of the main techniques of molecular biology related to the identification, manipulation and analysis of nucleic acids
- Recognition of the importance of different molecular biology techniques in the context of health sciences, in particular its importance in terms of molecular diagnosis and screening
- Recognition of the importance of molecular biology in scientific research
- Acquisition of laboratory skills on molecular biology techniques and in the establishment, maintenance and cellular and molecular characterization of human cell cultures

Learning outcomes and competences

Students must acquire an integrated and detailed view of the metabolic processes that involve nucleic acids, the occurrence of cell differentiation, and the major cellular and molecular changes associated with neoplasms.

Working method

Presencial

Program

Theoretical topics:
- Nucleic acids: general characteristics
- Molecular Biology Techniques and their application in Medicine
- DNA: structure of DNA, organization of genes and chromosomes, regulation of gene expression
- DNA replication
- DNA mutations and DNA repair systems
- DNA recombination techniques
- Structure and function of the different types of RNA: rRNA, tRNA and mRNA
- Transcription and splicing processes
- Synthesis and processing of rRNA
- Mechanism of protein translation
- Interference RNAs
- Stem cells and cell Differentiation
- Cancer: tumor suppressor genes and oncogenes

Theoretical-practical topics:
- Cellular and molecular techniques
- Establishment, maintenance and cellular and molecular characterization of human cell cultures

Mandatory literature

Cooper Geoffrey M.; The^cell. ISBN: 0-87893-220-7
Alberts Bruce 070; Essential Cell Biology. ISBN: 978-0-8153-4129-1
Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter; Molecular Biology of the Cell, 5th edition, Garland Science, 2007. ISBN: 978-0-8153-4106-2

Complementary Bibliography

Lodish Harvey 070; Molecular cell biology. ISBN: 0-7167-4366-3
Alberts Bruce 070; Molecular biology of the cell. ISBN: 0-8153-4072-9
Steven R Goodman; Medical Cell Biology, Academic Press, 2008
Carlos Azevedo/Claudio E. Sunkel; Biologia Celular e Molecular, 5ª Edição, Lidel, 2012

Teaching methods and learning activities

Theoretical classes of exposure of different themes, using a dynamic and ongoing participation of students. Interactive theoretical-practical classes, with an applied perspective of different topics related to the theoretical contents of the course. Practical classes oriented for the establishment, maintenance and cellular and molecular characterization of human cell cultures.

Software

Moodle

keywords

Natural sciences > Biological sciences > Biology > Human biology
Natural sciences > Biological sciences > Biology > Cell biology
Natural sciences > Biological sciences > Biology > Molecular biology
Natural sciences > Biological sciences > Biology > Clinical biology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	80,00
Teste	10,00
Trabalho laboratorial	10,00
Total:	100,00

Eligibility for exams

Minimum classification in the exam = 7.2 (maximum = 16)
Presence in 3/4 of the TP and P classes
Final classification > 9.5 values

Calculation formula of final grade

Final classification = classification in the theoretical exam (max 16 values) + classification in the theoretical-practical component (max 2 values) + classification in the practical component (max 2 values)

Special assessment (TE, DA, ...)

These students will be alowed to have alternative exam dates, in accordance with the law.