Molecular and Cell Biology II

Code:

MD1203

Acronym:

BCM II

Keywords
Classification	Keyword
OFICIAL	Biology

Instance: 2007/2008 - 2S

Active?	Yes
Course/CS Responsible:	Integrated Master in Dental Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMD	111	PLANO OFICIAL 2007/2008 BOLONHA	1	-	6	90	162

Teaching language

Portuguese

Program

Membrane structure: The Lipid Bilayer and membrane proteins. Membrane transport. The Electrical properties of membranes.
The nucleus: transport of molecules between the nucleus and the cytosol. Protein transport to the mitochondria. Peroxisomes and ER.
Intracellular vesicular traffic: transport from the ER though the Golgi apparatus. TRansport to the lysosomes. Endocytosis and Exocytosis
The Cytoskeleton. Cellular shape and mobility. Molecular motors.
Extracellular matrix.
Cell Communication. general principles of cell communication. Cell signalling.
Cell cycle and mitosis. Cell proliferation control, apoptosis and cancer.
Meiosis and fertilization.
Developmental Biology: biological models to study developmental biology. Segmentation and gastrulation in Xenopus Laevis. Genetic regulation andembryonic axis formation in Drosophila melanogaster.

Laboratory/practical classes:

Practical applications of DNA thecnology:
DNA fingerprinting
microsatellites PCR
Molecular diagnostics
Protein analysis: experimental questions
Nucleus and chromatin
organelles
Cell cycle analysis
Meiosis
Developmental biology:drosophila

Complementary Learning:

Discussion of a scientific papers and preparation of a seminar to present in the end of the semester:

Articles to discuss in class:

Drugs and addiction, ecstasy and cannabis
Botulinum Toxin as a Biological Weapon
Gene therapy for lysosomal storage diseases: the lessons and promise of animal models
Scurvy: historical review and current diagnostic approach
Role of stem cells in cancer therapy and cancer stem cells: a review


Themes for seminar presentation:

- Stem Cells and therapeutical prespectives
- Telomeres, aging and cancer
- Oral cancer biology
- Cencer therapies
- Medicine Nobel Prize 1986: Growth factors
-Medicine Nobel Prize 1989: cellular origin of retroviral oncogenes
-Medicine Nobel Prize 2001: Cell Cycle Regulators
- Medicine Nobel Prize 2002: Genetic regulation of organ development and programmed cell death
- Medicine Nobel Prize 2005: Helicobacter Pylori and gastritis
- Medicine Nobel Prize 2006: “RNA Interference
- Medicine Nobel Prize 2007: “Principles for introducing specific gene modifications in mice by the use of embryonic stem cells"

Mandatory literature

Alberts Bruce 070; Molecular biology of the cell. ISBN: 0-8153-4072-9
Cooper Geoffrey M.; The^cell. ISBN: 0-87893-220-7

Complementary Bibliography

Lodish Harvey 070; Molecular cell biology. ISBN: 0-7167-4366-3
Carlos Azevedo; Biologia Celular e Molecular, Lidel – Edições técnicas, 2005

Teaching methods and learning activities

Active learning
Laboratory/practical training
Paper discussions
Seminar preparation and presentation

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Subject Classes	Participação presencial	100,00
	Total:	-	0,00

Eligibility for exams

2 theoretical tests (T), 3 laboratory/practical tests(L) and Complementary Learning (L).

Theory evalulation (T)

Test organization:
20 Questions of the true/false type (10)
10 short answer questions- (10)

The first test contributes to 40% of the final classification
The second test contributes to 60% of the final classification

evaluation: 0-20
The students must have a minimum classification of 9.5

Laboratory/practical evaluation: (L)

The first test contributes to 30% of the final classification
The second test contributes to 20% of the final classification
The third test contributes to 50% of the final classification

evaluation: 0-20
The students must have a minimum classification of 9.5


Complementary Learning (C)

Paper Discussions (5)
Seminar preparation tutorials (5)
Seminar presentation and discussion (10)

evaluation: 0-20

Calculation formula of final grade

Theoretical evaluation (T) – 50%
Lab/Practical evaluation (L) – 30%
Complementary Learning (C) – 20%