In vitro study of the insulin-like action of vanadyl-pyrone and -pyridinone complexes with a VO(O-4) coordination mode

• Type: Article in International Scientific Journal
• Date: 2001

Authors

rangel, m (Author) ICBAS; tamura, a (Author) Other; fukushima, c (Author) Other; sakurai, h (Author) Other

Journal

Title: Journal of Biological Inorganic Chemistry

Vol. 6

Pages: 128-132

ISSN: 0949-8257

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 69 Citations

Scopus - 77 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-000-WH2

DOI: 10.1007/s007750000180

Abstract (EN): The insulin-like action of a novel class of potential insulin-mimetic complexes was investigated in terms of free fatty acid (FFA) release from isolated rat adipocytes. Vanadyl complexes such as VO(ema)(2) [bis(2-ethyl-3-hydroxy-4-pyrone)VO], VO(mpp)(2) [bis (3-hydroxy-2-methyl-4(1H)-pyridinone)VO], VO(dmpp)(2) [bis(1,2-dimethyl-3-hydroxy-4(1H)-pyridinone)VO] and VO(empp)(2) [bis(2-ethyl-3-hydroxy-1-methyl-4(1H)-pyridinone)VO] were tested together with vanadyl sulfate for comparison. The inhibitory effect of the vanadium complexes on FFA release, from rat adipocytes treated with epinephrine, is dependent on concentration and for that reason the results are reported in terms of the ICS, value, the 50% inhibition concentration. The results show that all the complexes have an inhibitory effect on FFA release and that two pyridinone complexes, VO(mpp)(2) and VO(empp)(2), have a significantly better insulin-mimetic activity than that of vanadyl sulfate.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5