Cerebrospinal fluid biomarkers: For the early diagnosis of Parkinson's disease [Biomarcadores no líquido cefalorraquidiano: Para o diagnóstico precoce de doença de Parkinson]

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

da Costa, AG (Author) Other; Gago, MF (Author) Other; Garrett, C (Author) FMUP

Journal

Title: Acta Medica Portuguesa

Vol. 24 No. 4

Pages: 761-768

ISSN: 0870-399X

Publisher: Ordem dos Medicos

Indexing

ISI Web of Knowledge

Scopus - 5 Citations

Other information

Authenticus ID: P-008-55M

Abstract (EN): In current medical practice, the diagnosis of Parkinson's disease remains essentially clinical. This practice determines that the diagnosis of Parkinson's disease is done in an already advanced neuropathological stage of the disease. The aim of this study is to review the validity of cerebrospinal fluid protein biological markers in the early diagnosis of Parkinson's disease. The ¿-synuclein and DJ-1 proteins, due to their role in the hereditary Parkinson's disease, have been the most widely studied cerebrospinal biomarkers. Nevertheless, they have had divergent results mostly owing to different processing, identification and control of laboratory techniques. The new proteomic techniques, directed to the detection of multiple undifferentiated proteins in cerebrospinal fluid (eg. ceruloplasmin, chromogranin B, apoH), are promising. The early diagnosis of Parkinson's disease is imperious as it is a progressive neurodegenerative disorder that causes extensive morbidity. Most of current scientific research in Parkinson's disease is focused on the discovery of neuroprotective drugs. Thus, the definition of biomarkers for the early diagnosis of Parkinson's disease is highly relevant.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8