Favipiravir (T-705) inhibits in vitro norovirus replication

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Rocha Pereira, J (Author) Other; Jochmans, D (Author) Other; Dallmeier, K (Author) Other; Leyssen, P (Author) Other; Nascimento, MSJ (Author) FFUP; Neyts, J (Author) Other

Journal

Title: Biochemical and Biophysical Research Communications

Vol. 424

Pages: 777-780

ISSN: 0006-291X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 66 Citations

Scopus - 21 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-6Z4

DOI: 10.1016/j.bbrc.2012.07.034

Abstract (EN): Human noroviruses are the primary cause of foodborne gastroenteritis. Potent and safe inhibitors are needed for the treatment/prophylaxis of norovirus infections. We demonstrate that Favipiravir [T-705, a drug in advanced clinical development for the treatment of infections with the influenza virus] inhibits in vitro murine norovirus replication. Time-of-drug addition studies reveal that T-705 exerts its activity at a time-point that coincides with onset of viral RNA synthesis, which is in line with the viral polymerase as the presumed target.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4