Suillus luteus methanolic extract inhibits proliferation and increases expression of p-H2A.X in a non-small cell lung cancer cell line

• Type: Article in International Scientific Journal
• Date: 2014

Authors

dos Santos, T (Author) Other; Oliveira, M (Author) FFUP; Sousa, D (Author) Other; Lima, RT (Author) Other; Martins, A (Author) Other; Ferreira, ICFR (Author) Other; Vasconcelos, MH (Author) FFUP

Journal

Title: Journal of Functional Foods

Vol. 6

Pages: 100-106

ISSN: 1756-4646

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-008-PK8

DOI: 10.1016/j.jff.2013.09.023

Abstract (EN): Methanolic extract of Suillus luteus was previously shown to inhibit proliferation of colon cancer cells with mutant p53. The effect of the same extract was further investigated here in a wildtype (wt) p53 non-small cell lung cancer cell line. Treatment with the extract increased the levels of p-H2A.X and the number of p-H2A.X foci/cell, indicating a possible increase in deoxyribonucleic acid (DNA) damage. Nevertheless, it did not cause alterations in wt p53 levels nor in programmed cell death. The extract caused inhibition of cellular proliferation and an increase in the % of cells in the G0/G1 phase of the cell cycle. In conclusion, even though there is evidence of DNA damage being caused by this extract, there is no induction of cell death in this p53 wt cell line.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7