Control of rocuronium-induced neuromuscular blockade via online identification of a two-parameters Wiener model

• Type: Article in International Conference Proceedings Book
• Date: 2012

Authors

Da Silva, MM (Author) Other; Rabico, R (Author) Other; Mendonca, T (Author) FCUP; Wigren, T (Author) Other

Conference proceedings International

Title: IFAC Proceedings Volumes (IFAC-PapersOnline)

Pages: 571-576

Universite Libre de Bruxelles

Bruxelles, 11 July 2012 through 13 July 2012

Indexing

ISI Web of Knowledge

Scopus - 5 Citations

Other information

Authenticus ID: P-008-6FX

DOI: 10.3182/20120711-3-be-2027.00267

Abstract (EN): A closed-loop controller for rocuronium-induced neuromuscular blockade using the first twitch of a train-of-four electromyographic stimulation as the measured signal is presented. Central to this development is the use of a two-parameters Wiener model, previously proposed to atracurium. The controller includes recursive parameters identification by an EKF, inversion of the nonlinearity using the current nonlinear parameter estimate and a pole placement controller for the exactly linearized system. Numerical tests on the performance of this adaptive structure were carried out on a bank of 500 simulated standard PK/PD models. The developed controller steers the neuromuscular blockade to a desired reference, tracking a constant or varying profile. It is also able to deal with parameter-varying systems and works well in noisy scenarios. These capabilities are crucial when testing this structure in a real clinical environment. © 2012 IFAC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6