Comparing different identification approaches for the depth of anesthesia using BIS measurements

• Type: Article in International Conference Proceedings Book
• Date: 2012

Authors

Mendonca, T (Author) FCUP; Alonso, H (Author) FEUP; Da Silva, MM (Author) Other; Esteves, S (Author) Other; Seabra, M (Author) Other

Conference proceedings International

Title: IFAC Proceedings Volumes (IFAC-PapersOnline)

Pages: 781-785

Universite Libre de Bruxelles

Bruxelles, 11 July 2012 through 13 July 2012

Indexing

ISI Web of Knowledge

Scopus - 16 Citations

Other information

Authenticus ID: P-008-6FS

DOI: 10.3182/20120711-3-be-2027.00323

Abstract (EN): Depth of anesthesia is usually quantified by the Bispectral Index (BIS) and refers to both loss of consciousness, resulting from the administration of a hypnotic like propofol, and inhibition of pain, resulting from the administration of an analgesic like remifentanil. This paper addresses the mathematical modeling of the joint effect of propofol and remifentanil in the depth of anesthesia, using BIS measurements. Two models and identification strategies are considered. The first model is based on standard pharmacokinetic/pharmacodynamic models and the associated identification strategy corresponds to the application of a hybrid method. The second model has a minimal number of parameters and the associated identification strategy corresponds to the application of a prediction error method. These two approaches are tested and compared on real data. © 2012 IFAC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5