Relative Y-STR mutation rates estimated from the variance inside SNP defined lineages

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Soares, PA (Author) Other; Pereira, F (Author) Other; Brion, M (Author) Other; Alves, C (Author) Other; Richards, M (Author) Other; Carracedo, A (Author) Other; Amorim, A (Author) FCUP; Gusmao, L (Author) Other

Journal

Title: International Congress Series

Vol. 1288

Pages: 82-84

ISSN: 0531-5131

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge

Scopus - 3 Citations

Other information

Authenticus ID: P-007-FDH

DOI: 10.1016/j.ics.2005.09.173

Abstract (EN): Y specific microsatellites (STRs) have been widely used in forensic and population genetics in age estimates of human male lineages. Previously, estimates of mutation rates from father-son pairs have given quite variable results in different studies, essentially due to the rarity of mutations. We propose an indirect approach for determining relative mutation rates of Y-chromosome microsatellites based on STR allele size intra-lineage variance. Indeed, the present distribution of STR alleles offers us an insight into the mechanisms that have generated that diversity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3