Evidence for population sub-structuring in Sao Tome e Principe as inferred from Y-chromosome STR analysis

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Trovoada, MJ (Author) Other; Alves, C (Author) Other; Gusmao, L (Author) Other; Abade, A (Author) Other; Amorim, A (Author) FCUP; Prata, MJ (Author) FCUP

Journal

Title: Annals of Human Genetics

Vol. 65

Pages: 271-283

ISSN: 0003-4800

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 20 Citations

Scientific classification

FOS: Natural sciences > Earth and related Environmental sciences

Other information

Authenticus ID: P-000-VJG

DOI: 10.1046/j.1469-1809.2001.6530271.x

Abstract (EN): Seven Y-chromosome STR loci, DYS19, DPS389I, DYS389II, DYS390: DYS391, DYS392 and DYX393 have been analysed in population samples of Angolares, Forros and Tong as; three ethnic groups from the African archipelago of Sao Tome e Principe (Gulf of Guinea). Complete typings were obtained for 103 chromosomes, which belonged to 79 different haplotypes. The mean heterozygosity per locus in the overall Sao Tomean sample was 0.566, with the highest value found among Forros and the lowest among Angolares. Angolares also showed the lowest level of haplotype diversity. On average, the mean pairwise difference between two random haplotypes from Angolares, Forros and Tongas was 4.69, 6.74 and 6.23 repeats, respectively. The genetic distances were found to be statistically significant between Angolares and Forros or Tongas. In accordance, AMOVA revealed that the percentage of variation attributable to differences among groups was only significant when we distinguished between Angolares and non-Angolares. Globally, these results indicate that, with respect to the pool of male lineages of Sao Tome e Principe, some genetic sub-structuring does exist, basically determined by the Angolares ethnic group.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13