Adenosine deaminase polymorphisms at the protein and DNA levels

• Type: Article in International Scientific Journal
• Date: 1999

Authors

Santos, F (Author) Other; Amorim, A (Author) FCUP; Rocha, J (Author) FCUP; Kompf, J (Author) Other

Journal

Title: Human Biology

Vol. 71

Pages: 1009-1013

ISSN: 0018-7143

Publisher: Wayne State University Press

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-001-2ND

Abstract (EN): Adenosine deaminase (ADA, E.C. 3.5.4.4) exhibits a well-known polymorphism at the protein level. We have studied ADA and an STR polymorphism exhibiting variation of a TTTA repeat motif at intron 3 of the ADA gene in random samples from northern Portugal (N = 218) and southwestern Germany (N = 114). The ADA phenotype distribution and population data on the worldwide distribution of ADA favor recurrent mutation as an explanation for the maintenance of the ADA*2 gene product at polymorphic frequencies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5