High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Teixeira, D (Author) Other; Vargens, D (Author) Other; Principe, A (Author) Other; Oliveira, E (Author) Other; Amorim, A (Author) FCUP; Prata, MJ (Author) FCUP; Suarez Kurtz, G (Author) Other

Journal

Title: Brazilian Journal of Medical and Biological Research

Vol. 43

Pages: 677-680

ISSN: 0100-879X

Publisher: Associacao Brasileira de Divulgacao Cientifica

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-003-531

DOI: 10.1590/s0100-879x2010007500056

Abstract (EN): A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the Sao Tome e Principe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. We combined these data with previously published results to carry out a multidimensional scaling analysis, which provided a visualization of the worldwide population affinities based on the GSTM3*A/*B polymorphism.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4