Nail changes secondary to docetaxel (Taxotere)

• Type: Article in International Scientific Journal
• Date: 1999

Authors

correia, o (Author) Other; azevedo, c (Author) Other; ferreira, ep (Author) Other; cruz, fb (Author) Other; polonia, j (Author) FMUP

Journal

Title: Dermatology

Vol. 198

Pages: 288-290

ISSN: 1018-8665

Publisher: Karger

Indexing

ISI Web of Knowledge - 49 Citations

Scopus - 65 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-001-5HM

DOI: 10.1159/000018132

Abstract (EN): Docetaxel is a new taxoid antineoplastic drug widely used for advanced breast cancer. Skin and nail toxicity are one of the more frequent nonhematologic adverse reactions. Besides dark pigmentations and Beau's lines, subungual hemorrhage, orange discoloration, acute painful paronychia, onycholysis, subungual hyperkeratosis and transverse loss of the nail plate are described. The type of nail alteration is related with the number of cycles administered and there are no efficacious preventive measures to avoid its development. Clinicians should recognize the clinical picture of these adverse nail reactions because docetaxel is used for several neoplastic disorders.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3