THE GLOMERULAR HYPERFILTRATION OF INSULIN-DEPENDENT DIABETES-MELLITUS MAY BE ASSOCIATED WITH ELEVATED PLASMA-LEVELS OF NORADRENALINE

• Type: Article in International Scientific Journal
• Date: 1988

Authors

CARVALHOBRAGA, D (Author) Other; NUNES, JP (Author) FMUP; ALMEIDA, R (Author) Other; AMARAL, I (Author) Other; HARGREAVES, MP (Author) Other; POLONIA, J (Author) FMUP

Journal

Title: Postgraduate Medical Journal

Vol. 64

Pages: 31-33

ISSN: 0032-5473

Publisher: BMJ PUBLISHING GROUP

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 2 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-001-TRA

Abstract (EN): To determine if adrenergic mechanisms can contribute to the glomerular hyperfiltration of early insulin-dependent diabetes mellitus (IDDM), we have studied plasma levels of noradrenaline (NA) and dopamine (DA) in eight normotensive, non-ketotic IDDM patients, with markedly elevated glomerular filtration rates, and in eight normal subjects as controls. NA was significantly higher in IDDM patients (median 414 pg/ml; range 260-1261) than in controls (251 pg/ml;range 118-465) (P < 0.05, Mann-Whitney U test). No significant differences could be found in DA levels. This study suggests that glomerular hyperfiltration of early IDDM is characterized by elevated plasma levels of NA, which may indicate an autoregulatory response to intrarenal haemodynamic abnormalities. However, the many differences, apart from glomerular filtration rate, between the patients and the control group selected make such an interpretation of our findings no more than tentative.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3