Contribution of the Portuguese Laboratory Network for the Diagnosis of Influenza A(H1N1)pdm09 Infection during the 2009/10 and 2010/11 influenza seasons

• Type: Article in International Scientific Journal
• Date: 2012

Authors

guiomar, r (Author) Other; pechirra, p (Author) Other; goncalves, p (Author) Other; arraiolos, a (Author) Other; conde, p (Author) Other; nunes, b (Author) Other; paixao, e (Author) Other; batista, i (Author) Other; furtado, c (Author) Other; machado, j (Author) Other; jose silvestre, m (Author) Other; almeida santos, m (Author) Other; sobrinho simoes, j (Author) Other; do rosario costa, m (Author) Other; tiago guimaraes, j (Author) FMUP; ribeiro, g (Author) Other; vaz, j (Author) Other; beleza, a (Author) Other; oliveira, r (Author) Other; fernandes, a (Author) Other; milho, l (Author) Other; rego, j (Author) Other; luisa fernandes, p (Author) Other; andrade, g (Author) Other; mota vieira, l (Author) Other; cabral veloso, r (Author) Other; bruges armas, j (Author) Other; pimentel couto, ar (Author) Other; marcelino, r (Author) Other; porta nova, t (Author) Other; melo cristino, j (Author) Other; carvalho, d (Author) Other; ribeiro, c (Author) Other; barreto, r (Author) Other; penim, v (Author) Other; corte real, r (Author) Other; branquinho, p (Author) Other; goncalves, l (Author) Other; helena ramos, m (Author) Other; paula castro, a (Author) Other; caldeira, f (Author) Other; maurilio, m (Author) Other

Journal

Title: Eurosurveillance

Vol. 17

Pages: 18-27

ISSN: 1560-7917

Publisher: European Centre for Disease Prevention and Control (ECDC)

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 2 Citations

Other information

Authenticus ID: P-008-PTY

Abstract (EN): This article describes the data obtained by the Portuguese Laboratory Network, reactivated following the World Health Organization declaration of the 2009 influenza pandemic, on the diagnoses of influenza A(H1N1)pdm09 infection during the pandemic (2009/10) and post-pandemic (2010/11) influenza seasons. The laboratories analysed and reported cases of influenza-like illness (ILI) and severe acute respiratory infection (SARI) to the National Influenza Reference Laboratory, which performed more detailed antigenic and genetic characterisation of the virus isolates. In 2009/10, a total of 62,089 ILI cases, distributed in two peaks, were analysed, 25,985 of which were positive for influenza A(H1N1) pdm09. Children aged 5-14 years were the most affected. Viruses were both antigenically and genetically similar to the pandemic strain A/California/7/2009, included in the 2009/10 pandemic vaccine. During the post-pandemic season, 1,496 ILI cases were tested for influenza A(H1N1)pdm09, 572 of which were positive. Infection was mainly diagnosed in adolescent and adults. Although the 2010/11 viruses remained antigenically similar to A/California/7/2009, increased genetic variation was observed. During the two seasons, two viruses with the neuraminidase H275Y amino acid substitution, associated with oseltamivir resistance, were detected. The Laboratory Network made an important contribution to the description of the influenza activity in the two seasons.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10