Apoptosis and physical exercise: Effects on skeletal muscle [Apoptose e exercício físico: Efeitos sobre o músculo esquelético]

• Type: Another Publication in an International Scientific Journal
• Date: 2008

Authors

voltarelli, fa (Author) Other; de mello, mar (Author) Other; ramos duarte, ja (Author) FADEUP

Journal

Title: Revista Brasileira de Cineantropometria & Desempenho Humano

Vol. 10

Pages: 100-105

ISSN: 1415-8426

Publisher: Universidade Federal de Santa Catarina (UFSC)

Indexing

ISI Web of Knowledge

Scopus - 0 Citations

Other information

Authenticus ID: P-009-5S8

DOI: 10.5007/1980-0037.2008v10n1p100

Abstract (EN): This brief review will discuss an exciting new area in exercise science, namely the role of apoptosis programmed cell death in exercise. Apoptotic cell death differs morphologically and biochemically from necrotic cell death, although both appear to occur after exercise. Accelerated apoptosis has been documented to occur in a variety of disease states, such as AIDS and Alzheimer's disease, as well as in the aging heart. In striking contrast, failure to activate this genetically regulated cell death may result in cancer and certain viral infections. Here, the apoptosis phenomenon will be discussed, as it occurs in skeletal muscle, and its relation to physical exercise, as well as the interaction with the HSP70 protein. We speculate that exercise-induced apoptosis is a normal regulatory process that serves to remove certain damaged cells without a pronounced inflammatory response, thus ensuring optimal organism function.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6