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p63 expression in solid cell nests of the thyroid: Further evidence for a stem cell origin

Title
p63 expression in solid cell nests of the thyroid: Further evidence for a stem cell origin
Type
Article in International Scientific Journal
Year
2003
Authors
Reis, JS
(Author)
Other
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Preto, A
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Ricardo, S
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Cameselle Teijeiro, J
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Sobrinho Simoes, M
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Journal
Title: Modern PathologyImported from Authenticus Search for Journal Publications
Vol. 16
Pages: 43-48
ISSN: 0893-3952
Publisher: Springer Nature
Scientific classification
FOS: Medical and Health sciences > Basic medicine
Other information
Authenticus ID: P-000-K5S
Abstract (EN): Solid cell nests of the thyroid are embryonic remnants of endodermal origin that may be difficult to distinguish from squamous metaplasia, metastatic squamous carcinoma, papillary microcarcinoma, medullary carcinoma, and C-cell hyperplasia. These embryonic structures are composed of main cells and C-cells; cystic structures and mixed follicles are sometimes observed intermingled with solid cell nests. Recently, p63, a p53 homologue that is consistently expressed in basal/stem cells of stratified epithelia and plays a major role in triggering the differentiation of some specific cell lineages, has been characterized. We evaluated the immunohistochemical expression of p63, cytokeratins (CAM 5.2, AE1/AE3,34betaE12,7, and 20), carcinoembryonic antigen, thyroid transcription factor 1 (ITF-1), thyroglobulin, and calcitonin using the streptavidin-biotin-peroxidase complex technique in 6 bona fide solid cell nests. We observed that main cells of solid cell nests are strongly decorated by p63, while C-cells and all other thyroid structures were consistently negative. Moreover, main cells expressed carcinoembryonic antigen and all cytokeratins but cytokeratin 20 and lacked TTF-1, thyroglobulin and calcitonin. In contrast to this, C-cells of solid cell nests were immunoreactive for calcitonin, CAM 5.2, AE1/AE3, and cytokeratin 7; focal immunoreactivity for TIPF-1 was also observed in some C-cells. We conclude that main cells of the solid cell nests display a basal/stem cell phenotype (p63 and basal cytokeratin positivity), whereas C-cells show features of parafollicular differentiation. We conclude, furthermore, that p63 antibodies may help in distinguishing solid cell nests from their mimics.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
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