Human serum alcaline phosphatase and ageing [Fosfátase alcalina sérica humana e envelhecimento]

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Negrao, MR (Author) FMUP; Martins, MJ (Author) FMUP; Ramos, E (Author) Other; Barros, H (Author) FMUP; Hipolito Reis, C (Author) Other; Azevedo, I (Author) Other

Journal

Title: Acta Medica Portuguesa

Vol. 16 No. 3

Pages: 395-400

ISSN: 0870-399X

Publisher: Ordem dos Medicos

Indexing

ISI Web of Knowledge

Scopus - 2 Citations

Other information

Authenticus ID: P-008-KHC

Abstract (EN): Background: In experimental ageing models an inverse relationship between age and alkaline phosphatase activity has been observed. Objective: To characterize serum levels of alkaline phosphatase activity in humans according to age and gender. Methods: Serum alkaline phosphatase was determined in a random sample of 203 community dwellers aged 40 or more years. Results: In men (n=87) total serum alkaline phosphatase markedly increased from the 5 th to the 6 th decade and then stabilized. For women (n=116) there was a slight increase in total serum alkaline phosphatase from the 5 th to the 6 th decade, followed by a bend upward after 69 years of age. There was a significant positive correlation between total serum alkaline phosphatase and age for the whole population. Conclusions: Serum alkaline phosphatase activity appears as a biomarker of age in humans, similarly to what has been described for experimental animal models.

Language: Portuguese

Type (Professor's evaluation): Scientific

No. of pages: 6