Influence of dietary supplementation with dextrin or oligofructose on the hepatic redox balance in rats

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Carina E P Kozmus (Author) Other; Eduardo Moura (Author) Other; Maria P Serrao (Author) Other; Helena Real (Author) Other; Joao T Guimaraes (Author) FMUP; Guedes de Pinho, P (Author) FFUP; Barbara P Duarte (Author) Other; Franklim Marques (Author) FFUP; Maria Joao Martins (Author) FMUP; Maria A Vieira Coelho (Author) FMUP

Journal

Title: Molecular Nutrition and Food Research

Vol. 55

Pages: 1735-1739

ISSN: 1613-4125

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 15 Citations

Scientific classification

FOS: Agrarian Sciences > Other Agrarian Sciences

Other information

Authenticus ID: P-002-JYN

DOI: 10.1002/mnfr.201100287

Abstract (EN): We assessed the impact of oligofructose (OFS) and dextrin (DEX) as diet supplements on hepatic redox state. Rats were fed either a 10% OFS or a 10% DEX supplemented diet for 9 wk. In the DEX diet group, the levels of hepatic protein carbonylation were decreased by 63%. Total glutathione and reduced glutathione (GSH) contents were reduced in the OFS and DEX diet groups by around 20%. DEX supplementation significantly reduced oxidized glutathione (GSSG) levels resulting in a 33% increase in the GSH/GSSG ratio. The activity of the hepatic antioxidant enzymes was not changed by either OFS or DEX supplementation. OFS supplementation caused a decrease in serum levels of triglycerides (36%), cholesterol (24%), HDL (16%) and LDL (17%). DEX supplementation only reduced triglycerides (32%) and urea (22%). Both diets increased serum levels of acetate by fivefold and propionate by twofold, but DEX diet decreased butyrate levels by 75%. Due to their different composition/structure these two dietary fibers affected metabolism in different ways. Diet supplementation with 10% DEX can potentially improve host health, by protecting the liver from protein carbonylation and by improving GSH/GSSG ratio and diet supplementation with 10% OFS can improve the lipid profile.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5